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World J Gastroenterol. Aug 28, 2022; 28(32): 4516-4526
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4516
Expanding beyond endoscopy: A review of non-invasive modalities in Barrett’s esophagus screening and surveillance
Dariush Shahsavari, Praneeth Kudaravalli, John Erikson L Yap, Kenneth J Vega
Dariush Shahsavari, Praneeth Kudaravalli, John Erikson L Yap, Kenneth J Vega, Division of Gastroenterology and Hepatology, Augusta University-Medical College of Georgia, Augusta, GA 30912, United States
Author contributions: Shahsavari D performed the majority of the writing and prepared tables, Kudaravalli P contributed to writing and prepared figures; Yap JEL provided input in writing the paper; Vega KJ designed the outline, coordinated the writing of the paper, edited the paper for intellectual content and is the guarantor.
Conflict-of-interest statement: No conflict of interest exists for any author of this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kenneth J Vega, AGAF, FACG, FACP, MD, Professor, Division of Gastroenterology and Hepatology, Augusta University-Medical College of Georgia, 1120 15th Street AD 2226, Augusta, GA 30912, United States. kvega@augusta.edu
Received: January 14, 2022
Peer-review started: January 14, 2022
First decision: April 12, 2022
Revised: May 14, 2022
Accepted: July 26, 2022
Article in press: July 26, 2022
Published online: August 28, 2022
Core Tip

Core Tip: This review summarizes the non-endoscopic modalities available for the screening and surveillance of Barrett’s esophagus which include esophageal imaging devices (trans-nasal endoscopy, esophageal capsule, tethered capsule endomicroscopy), cell collection devices (Cytosponge, Esophacap, Esocheck), circulatory micro-RNAs and volatile organic compounds. There is promise using some of the noninvasive modalities for mass screening in BE and a role in surveillance is yet to be determined.