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World J Gastroenterol. Aug 28, 2022; 28(32): 4493-4507
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4493
Who to screen and how to screen for celiac disease
Prashant Singh, Achintya Dinesh Singh, Vineet Ahuja, Govind K Makharia
Prashant Singh, Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, United States
Achintya Dinesh Singh, Department of Medicine, Cleveland Clinic, Cleveland, OH 44195, United States
Vineet Ahuja, Govind K Makharia, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India
Author contributions: Singh P and Makharia GK were involved in review concept and the article structure; Singh P, Singh AD were involved in data collection and writing the first draft of the manuscript; All the authors contributed in reviewing and editing the final draft of the manuscript.
Conflict-of-interest statement: There are no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Govind K Makharia, MBBS, MD, DM, Professor, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. govindmakharia@gmail.com
Received: December 31, 2021
Peer-review started: December 31, 2021
First decision: January 27, 2022
Revised: March 3, 2022
Accepted: June 16, 2022
Article in press: June 16, 2022
Published online: August 28, 2022
Core Tip

Core Tip: In this review article, we have summarized the available literature about the prevalence of celiac disease (CeD) in various gastrointestinal (chronic diarrhea) and non-gastrointestinal conditions (such as iron deficiency anemia, short stature, cryptogenic hypertransaminesemia, cryptogenic cirrhosis or idiopathic ataxia etc.).We thereby share the various clinical indications for screening for CeD. Also, we elucidate the diagnostic performance of various serological assays along with their limitations and propose an algorithm to diagnose patients with suspected CeD.