Gligorijević N, Minić S, Nedić O. Structural changes of proteins in liver cirrhosis and consequential changes in their function. World J Gastroenterol 2022; 28(29): 3780-3792 [PMID: 36157540 DOI: 10.3748/wjg.v28.i29.3780]
Corresponding Author of This Article
Nikola Gligorijević, PhD, Research Associate, Department of Metabolism, University of Belgrade-Institute for the Application of Nuclear Energy, Banatska 31b, Belgrade 11080, Serbia. nikolag@inep.co.rs
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 7, 2022; 28(29): 3780-3792 Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3780
Structural changes of proteins in liver cirrhosis and consequential changes in their function
Nikola Gligorijević, Simeon Minić, Olgica Nedić
Nikola Gligorijević, Olgica Nedić, Department of Metabolism, University of Belgrade-Institute for the Application of Nuclear Energy, Belgrade 11080, Serbia
Simeon Minić, Centre of Excellence for Molecular Food Sciences and Department of Biochemistry, University of Belgrade-Faculty of Chemistry, Belgrade 11000, Serbia
Author contributions: Gligorijevic N performed the literature search, writing and prepared the figure; Minic S performed the literature search and writing; Nedic O designed the outline, performed the literature search and coordinated the writing of the paper.
Supported bythe Ministry of Education, Science and Technological Development of the Republic of Serbia, No. 451-03-9/2021-14/200019.
Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nikola Gligorijević, PhD, Research Associate, Department of Metabolism, University of Belgrade-Institute for the Application of Nuclear Energy, Banatska 31b, Belgrade 11080, Serbia. nikolag@inep.co.rs
Received: January 13, 2022 Peer-review started: January 13, 2022 First decision: May 29, 2022 Revised: May 30, 2022 Accepted: June 30, 2022 Article in press: June 30, 2022 Published online: August 7, 2022 Processing time: 201 Days and 21.3 Hours
Core Tip
Core Tip: Chronic liver diseases and cirrhosis are accompanied by various metabolic disorders, some of which affect proteins. Besides changes in the concentration, structural alterations of proteins occur, mostly at the level of posttranslational modifications (PTMs). Five frequent cirrhosis-related PTMs are oxidation, nitration, glycosylation, acetylation, and ubiquitination. Some are more specific for the circulating proteins, whereas others are more specific for liver tissue-residing proteins. PTMs influence folding, stability, half-life, aggregation, and function of proteins. Modified proteins with altered function contribute to further progression of liver pathology. An overview of cirrhosis-related alterations of PTMs of specific proteins is the topic of this article.
