Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2022; 28(28): 3706-3719
Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3706
Family-based Helicobacter pylori infection status and transmission pattern in central China, and its clinical implications for related disease prevention
Xue-Chun Yu, Qiao-Qiao Shao, Jing Ma, Miao Yu, Chen Zhang, Lei Lei, Yang Zhou, Wen-Chao Chen, Wei Zhang, Xin-Hui Fang, Yuan-Zeng Zhu, Gang Wu, Xue-Mei Wang, Shuang-Yin Han, Pei-Chun Sun, Song-Ze Ding
Xue-Chun Yu, Qiao-Qiao Shao, Jing Ma, Miao Yu, Lei Lei, Xin-Hui Fang, Shuang-Yin Han, Song-Ze Ding, Department of Gastroenterology and Hepatology, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Chen Zhang, Department of Gastroenterology and Hepatology, Henan University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Yang Zhou, Wen-Chao Chen, Wei Zhang, Yuan-Zeng Zhu, Gang Wu, Pei-Chun Sun, Department of Gastrointestinal Surgery, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Xue-Mei Wang, Department of Traditional Chinese Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Author contributions: Ding SZ, Wu G, Wang XM, Han SY and Sun PC conceived and designed the study; Yu XC, Shao QQ, Zhang C and Yu M searched and screened related literature; Yu XC, Shao QQ, Ma J, Lei L and Zhou Y performed the data extraction and quality assessment; Yu XC, Zhou Y, Chen WC, Zhang W, Fang XH and Zhu YZ analyzed the data; Yu XC and Ding SZ wrote the manuscript; all authors critically revised and approved the final version of the manuscript.
Supported by National Natural Science Foundation of China, No. U1604174; Henan Provincial Government-Health and Family Planning Commission, No. 20170123 and No. SBGJ202002004; and Henan Provincial Government-Health and Family Planning Commission Research Innovative Talents Project, No. 51282.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of People’s Hospital of Zhengzhou University, 2021, No. 53.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Song-Ze Ding, MD, PhD, Professor, Department of Gastroenterology and Hepatology, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, No. 7 Weiwu Road, Jin Shui District, Zhengzhou 450003, Henan Province, China. dingsongze@hotmail.com
Received: April 18, 2022
Peer-review started: April 18, 2022
First decision: May 29, 2022
Revised: June 9, 2022
Accepted: June 24, 2022
Article in press: June 24, 2022
Published online: July 28, 2022
Core Tip

Core Tip: Helicobacter pylori (H. pylori) has characteristics of family cluster infection. However, few studies have investigated family-based infection status and pattern of intrafamilial transmission in the general public of central China. In our study, H. pylori infection rate was 54.27%, but in 87.23% of healthy households, there was at least 1 H. pylori-infected person; in 27.24% of these infected families, all members were infected. Type I H. pylori was the dominant strain in this area. Intrafamilial infection status and patterns of transmission represent one important source of H. pylori spread, indicating the urgent need for family-based infection control and related disease prevention.