Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2022; 28(26): 3218-3231
Published online Jul 14, 2022. doi: 10.3748/wjg.v28.i26.3218
Published online Jul 14, 2022. doi: 10.3748/wjg.v28.i26.3218
Divergent trajectories of lean vs obese non-alcoholic steatohepatitis patients from listing to post-transplant: A retrospective cohort study
Fakhar Ali Qazi-Arisar, Raj Uchila, Catherine Chen, Cathy Yang, Ravikiran Sindhuvalada Karnam, Amirhossein Azhie, Zita Galvin, Nazia Selzner, Leslie Lilly, Mamatha Bhat, Ajmera Transplant Program, Toronto General Hospital, University Health Network, Toronto M5G 2N2, Ontario, Canada
Fakhar Ali Qazi-Arisar, Raj Uchila, Ravikiran Sindhuvalada Karnam, Zita Galvin, Nazia Selzner, Leslie Lilly, Mamatha Bhat, Division of Gastroenterology and Hepatology, Department of Medicine, University of Toronto, Toronto M5G 2N2, Ontario, Canada
Fakhar Ali Qazi-Arisar, National Institute of Liver and GI Diseases, Dow University of Health Sciences, Karachi 75330, Pakistan
Shi-Yi Chen, Wei Xu, Department of Biostatistics, Princess Margaret Cancer Center, University Health Network, Toronto M5G 2C1, Ontario, Canada
Wei Xu, Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto M5G 2C1, Ontario, Canada
Author contributions: Qazi-Arisar FA and Uchila R given their equal contribution in the manuscript; Bhat M was the guarantor and designed the study; Qazi-Arisar FA, Uchila R, Chen C, Yang C, Chen SY, Karnam RS and Azhie A participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Qazi-Arisar FA, Xu W, Galvin Z, Selzner N, Lilly L and Bhat M revised the article critically for important intellectual content.
Institutional review board statement: The study was reviewed and approved by the Research Ethics board of the University Health Network (Toronto, Canada).
Informed consent statement: Given retrospective nature of study from chart review, written informed consent was not required.
Conflict-of-interest statement: Dr. Bhat reports other from Novo Nordisk, other from Ipsen, grants from Paladin, grants from Natera, grants from Oncoustics, grants from MedoAI, grants from Lallemand, personal fees from Novartis, personal fees from Lupin, outside the submitted work.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mamatha Bhat, FRCP (C), MD, PhD, Assistant Professor, Ajmera Transplant Program, Toronto General Hospital, University Health Network, 585 University Ave, 11th Floor, Room 183, Toronto M5G 2N2, Ontario, Canada. mbhat33@gmail.com
Received: February 3, 2022
Peer-review started: February 3, 2022
First decision: April 10, 2022
Revised: April 22, 2022
Accepted: June 15, 2022
Article in press: June 15, 2022
Published online: July 14, 2022
Peer-review started: February 3, 2022
First decision: April 10, 2022
Revised: April 22, 2022
Accepted: June 15, 2022
Article in press: June 15, 2022
Published online: July 14, 2022
Core Tip
Core Tip: Non-alcoholic steatohepatitis continues to rise as an indication for liver transplantation (LT). In this study, we analyzed our single-center data of adult patients listed for LT between 2012 and 2019 and reported their outcomes on the waitlist as well as post-LT based on their body mass index.