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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2022; 28(26): 3027-3046
Published online Jul 14, 2022. doi: 10.3748/wjg.v28.i26.3027
Published online Jul 14, 2022. doi: 10.3748/wjg.v28.i26.3027
Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance
María Belén Novoa Díaz, María Julia Martín, Claudia Gentili, Departamento de Biología, Bioquí
María Julia Martín, Departamento de Química, Universidad Nacional del Sur (UNS)-INQUISUR (CONICET-UNS), Bahía Blanca 8000, Argentina
Author contributions: Novoa Díaz MB, Martín MJ, and Gentili C contributed to the conceptualization, methodology, investigation, formal analysis, and visualization, wrote the original draft, and edited the manuscript; Gentili C obtained the resources and oversaw the project administration and funding acquisition.
Supported by Agencia Nacional de Promoción Científica y Tecnológica , No. PICT-2013-1441 ; Consejo Nacional de Investigaciones Científicas y Técnicas , No. PIP11220150100350 ; Instituto Nacional del Cáncer Asistencia Financiera II , RESOL 493/14, No. 2002-4395-14-1; Instituto Nacional del Cáncer Asistencia Financiera II I-2016-2017, RESOL-2016-1006-E-APN-MS, No. 2002-3862-16-1; and Universidad Nacional del Sur (PGI) , Argentina, No. 24/B230 and No. 24/B303.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: María Julia Martín, PhD, Research Assistant, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)-INBIOSUR (CONICET-UNS), San Juan 670, Bahía Blanca 8000, Argentina. julia.martin@uns.edu.ar
Received: December 21, 2021
Peer-review started: December 21, 2021
First decision: March 10, 2022
Revised: April 29, 2022
Accepted: June 20, 2022
Article in press: June 20, 2022
Published online: July 14, 2022
Peer-review started: December 21, 2021
First decision: March 10, 2022
Revised: April 29, 2022
Accepted: June 20, 2022
Article in press: June 20, 2022
Published online: July 14, 2022
Core Tip
Core Tip: Currently, there is a high probability of failure in treatments for the advanced stages of colorectal cancer (CRC). For this reason, it is necessary to obtain a better understanding of CRC biology in a more global context for the future design of novel therapeutic approaches. The effects of the Wnt/β-catenin signaling pathway and the tumor microenvironment (TME) on the progression and chemoresistance of this disease were separately described in several review articles. Therefore, herein we comprehensively analyze the complex mechanisms of CRC chemoresistance triggered by TME factors that impact Wnt/β-catenin signaling.