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World J Gastroenterol. Jun 28, 2022; 28(24): 2680-2688
Published online Jun 28, 2022. doi: 10.3748/wjg.v28.i24.2680
Pancreatic involvement in celiac disease
Daniel Vasile Balaban, Iulia Enache, Marina Ciochina, Alina Popp, Mariana Jinga
Daniel Vasile Balaban, Iulia Enache, Marina Ciochina, Mariana Jinga, Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania
Daniel Vasile Balaban, Iulia Enache, Marina Ciochina, Mariana Jinga, Dr. Carol Davila Central Military Emergency University Hospital, Bucharest 020021, Romania
Alina Popp, Department of Pediatrics, Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania
Alina Popp, National Institute for Mother and Child Health, Bucharest 020021, Romania
Author contributions: Balaban DV proposed the research idea; Balaban DV, Enache I, and Ciochina M performed the literature search and article selection, and drafted the initial version of the manuscript; Popp A and Jinga M critically reviewed the manuscript and supervised the project; All authors contributed to drawing the figures and tables, and have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Daniel Vasile Balaban, MD, PhD, Senior Lecturer, Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, 134 Calea Plevnei, Bucharest 020021, Romania. vbalaban@yahoo.com
Received: January 15, 2022
Peer-review started: January 15, 2022
First decision: April 12, 2022
Revised: April 17, 2022
Accepted: May 27, 2022
Article in press: May 27, 2022
Published online: June 28, 2022
Core Tip

Core Tip: Celiac disease (CD) is currently regarded as a systemic, chronic, immune-mediated disease triggered by gluten ingestion in genetically susceptible individuals. In the last decade there has been an increasing number of publications on extraintestinal involvement during the course of CD, some of which have assessed the pancreatic changes associated with this disease. This review summarizes currently available data with respect to exocrine pancreatic changes in CD, focusing on practices for clinicians.