Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2022; 28(23): 2569-2581
Published online Jun 21, 2022. doi: 10.3748/wjg.v28.i23.2569
Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol
Yi-Xin Guo, Bing Han, Ting Yang, Yu-Si Chen, Yi Yang, Jia-Yao Li, Qin Yang, Ru-Jia Xie
Yi-Xin Guo, Jia-Yao Li, Department of Pathophysiology, Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Bing Han, Ting Yang, Yu-Si Chen, Yi Yang, Qin Yang, Ru-Jia Xie, Department of Pathophysiology, College of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Author contributions: Yang Q and Xie RJ designed and coordinated the study; Guo YX, Han B and Yang T performed the experiments and acquired data; Chen YS, Yang Y and Li JY analyzed and interpreted data; Guo YX and Xie RJ drafted the manuscript; all authors approved the final version of the article.
Supported by National Natural Science Foundation of China, No. 81560105; Science and Technology Foundation of Guizhou Province, No. Qiankehe Jichu-ZK[2021]365, and No. Qiankehe Pingtai Rencai[2019]5801; and National Natural Science Foundation Cultivation Project of Guizhou Medical University, No. 20NSP016.
Institutional review board statement: This study did not involve human subjects or living animals.
Institutional animal care and use committee statement: This study did not involve human subjects or living animals.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author at 592153968@qq.com upon request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ru-Jia Xie, MD, Academic Research, Department of Pathophysiology, College of Basic Medical Sciences, Guizhou Medical University, Dongqing Road, Guiyang 550025, Guizhou Province, China. 592153968@qq.com
Received: January 5, 2022
Peer-review started: January 5, 2022
First decision: March 9, 2022
Revised: March 23, 2022
Accepted: April 29, 2022
Article in press: April 29, 2022
Published online: June 21, 2022
Processing time: 162 Days and 7.6 Hours
Core Tip

Core Tip: We show that family with sequence similarity 134 member B (FAM134B)-mediated reticulophagy maintains the endoplasmic reticulum (ER) homeostasis in ER-stressed hepatocytes via the clearance of damaged ER fragments. Thereby FAM134B-mediated reticulophagy ameliorates dithiothreitol-induced hepatocyte apoptosis. Our findings provide emerging evidence of the prominence of ER-phagy in ER stress-related hepatocyte apoptosis. FAM134B may represent a potential therapeutic target for liver disease treatment.