Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2022; 28(22): 2429-2436
Published online Jun 14, 2022. doi: 10.3748/wjg.v28.i22.2429
Metabolic aspects of hepatitis C virus
Mohamed El-Kassas, Abeer Awad
Mohamed El-Kassas, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo 11795, Egypt
Abeer Awad, Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo 11566, Egypt
Author contributions: El-Kassas M conceptualized the idea, revised and edited the final manuscript; Awad A drafted the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mohamed El-Kassas, MD, Full Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Helwan, Cairo 11795, Egypt.
Received: January 6, 2022
Peer-review started: January 6, 2022
First decision: March 9, 2022
Revised: March 18, 2022
Accepted: April 22, 2022
Article in press: April 22, 2022
Published online: June 14, 2022
Processing time: 154 Days and 10.1 Hours
Core Tip

Core Tip: Hepatitis C virus (HCV) infection has several metabolic aspects that are largely well understood; as such, HCV is nowadays considered a systemic disease rather than a local disease with different metabolic consequences. Moreover, these metabolic factors may affect the natural history of chronic liver disease and of diseases not related to the liver, which constitute a significant burden on the overall health of the human body, with an increased economic burden to patients, healthcare systems, and society if not adequately addressed and appropriately managed. More studies are needed to evaluate metabolic aspects associated with HCV infection and delineate their effects and the long-term outcome of antiviral therapies.