Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2022; 28(21): 2396-2402
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2396
Peripancreatic paraganglioma: Lesson from a round table
Federica Petrelli, Geri Fratini, Andrea Sbrozzi-Vanni, Andrea Giusti, Raffele Manta, Claudio Vignali, Gabriella Nesi, Andrea Amorosi, Andrea Cavazzana, Marco Arganini, Maria Raffaella Ambrosio
Federica Petrelli, Andrea Giusti, Andrea Cavazzana, Maria Raffaella Ambrosio, Pathology Unit, Azienda Sanitaria Toscana Nord Ovest, Pisa 56121, Italy
Geri Fratini, Marco Arganini, Surgery Unit, Azienda Sanitaria Toscana Nord Ovest, Pisa 56121, Italy
Andrea Sbrozzi-Vanni, Endoscopic Unit, Azienda Sanitaria Toscana Nord Ovest, Pisa 56121, Italy
Raffele Manta, Endoscopic Unit, Santa Maria Misericordia Hospital, Perugia 06122, Italy
Claudio Vignali, Interventional Radiology Unit, Azienda Sanitaria Toscana Nord Ovest, Pisa 56121, Italy
Gabriella Nesi, Department of Health Sciences, University of Florence, Florence 50139, Italy
Andrea Amorosi, Pathology Unit, Università Magna Graecia, Catanzaro 88100, Italy
Author contributions: Ambrosio MR, Amorosi A, and Arganini M contributed to the conception and design; Fratini G and Sbrozzi-Vanni A acquired the data; Cavazzana A, Giusti A, and Nesi G analyzed and interpreted of the data; Ambrosio MR, Fratini G, and Petrelli F drafted the article; Amorosi A, Arganini M, Manta R, Nesi G, and Vignali C contributed to the critical revision of the article for important intellectual content; and all authors approved the final manuscript to be published.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maria Raffaella Ambrosio, PhD, Academic Research, Chief Doctor, Pathology Unit, Azienda Sanitaria Toscana Nord Ovest, Via Cocchi, Pisa 56121, Italy. mariaraffaella.ambrosio@uslnordovest.toscana.it
Received: December 7, 2021
Peer-review started: December 7, 2021
First decision: January 8, 2022
Revised: January 18, 2022
Accepted: May 14, 2022
Article in press: May 14, 2022
Published online: June 7, 2022
Processing time: 176 Days and 19.9 Hours
Core Tip

Core Tip: Our report strongly supports that paraganglioma should be included in the differential diagnosis of peripancreatic/pancreatic masses, highlighting the difficulties in establishing the accurate preoperative diagnosis, even after a second-round evaluation. In fact, due to the deep localization and the lack of specific clinical manifestations and imaging data, early diagnosis often relies solely on a level of suspicion, thus making it more probable to have a missed diagnosis or misdiagnosis. Moreover, the limited time spent with a patient in an emergency setting might impair the accuracy of the diagnosis, lowering quality and outcomes of healthcare delivery. A multidisciplinary team approach, involving skilled radiologists, endoscopists, pathologists, and surgeons, is of foremost importance for proper diagnosis and management, preventing undue surgical resections.