Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2022; 28(21): 2383-2395
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2383
Endoscopic ultrasound-guided injectable therapy for pancreatic cancer: A systematic review
Jyotroop Kaur, Veeravich Jaruvongvanich, Vinay Chandrasekhara
Jyotroop Kaur, Veeravich Jaruvongvanich, Vinay Chandrasekhara, Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: Kaur J and Chandrasekhara V conceived and designed the study and critically reviewed the manuscript; Kaur J and Chandrasekhara V conducted the literature search, screened for eligibility, and drafted the manuscript; Kaur J and Jaruvongvanich V collected, analyzed, and interpreted the data; all authors reviewed the literature and revised the manuscript, read and approved the final manuscript.
Conflict-of-interest statement: There are no conflicts of interest to report.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vinay Chandrasekhara, FASGE, MD, Associate Professor, Attending Doctor, Department of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States. chandrasekhara.vinay@mayo.edu
Received: December 10, 2021
Peer-review started: December 10, 2021
First decision: January 8, 2022
Revised: January 18, 2022
Accepted: April 22, 2022
Article in press: April 22, 2022
Published online: June 7, 2022
Processing time: 173 Days and 14.6 Hours
Core Tip

Core Tip: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. Resistance to systemic therapies may be attributable to the dense stromal matrix in the pancreatic tumor mass. Endoscopic ultrasound-guided fine-needle injection (EUS-FNI) is a novel technique to deliver various anti-tumor agents locally in real-time and may overcome this limitation. This review examines the EUS-FNI therapies used to treat PDAC.