Retrospective Cohort Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2022; 28(14): 1455-1478
Published online Apr 14, 2022. doi: 10.3748/wjg.v28.i14.1455
Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum: A case series and systematic literature review
Michael T LeCompte, Brandon Mason, Keenan J Robbins, Motoyo Yano, Deyali Chatterjee, Ryan C Fields, Steven M Strasberg, William G Hawkins
Michael T LeCompte, Department of Surgical Oncology, University of North Carolina, Raleigh, NC 27608, United States
Brandon Mason, Department of Radiology, Stillwater Medical Center, Stillwater, OK 74074, United States
Keenan J Robbins, Department of General Surgery, Washington University St. Louis, St. Louis, MO 63110-8109, United States
Motoyo Yano, Department of Radiology, Mayo Clinic, Phoenix, AZ 8505, United States
Deyali Chatterjee, Department of Pathology and Immunology, MD Anderson Cancer Center, Houston, TX 77030, United States
Ryan C Fields, Department of Surgical Oncology, Washington University School of Medicine, St. Louis, MO 63110-8109, United States
Steven M Strasberg, William G Hawkins, Section of Hepatobiliary-Pancreatic and GI Surgery, Washington University St. Louis, St. Louis, MO 63110, United States
Author contributions: LeCompte M designed the study and performed the research, reviewed the manuscripts and wrote the paper; Mason B and Yano M reviewed the radiographic images and contributed content to the manuscript regarding radiographic identification; Chatterjee D collected and reviewed pathologic specimens; Robbins K assisted in reviewing medical records and collecting data; Hawkins G, Strasberg S, and Fields R participated in designing the study and contributed to the analysis and editing of the manuscript.
Institutional review board statement: This study was reviewed and approved by the institutional review board of Washington University of St. Louis. IRB number [#210811062].
Informed consent statement: Based on the study protocol and design, informed consent was determined to not be required and was therefore not obtained for this study. Patient information was collected and reviewed based on the parameters laid out by the IRB at our institution and was deidentified for analysis and reporting. The remainder of the study population was constructed based on a cohort of patients obtained through systematic review of the literature and was therefore based on patient information which had already been published and presented in the literature. For further questions or concerns please feel free to contact the corresponding author.
Conflict-of-interest statement: The authors of this study have no related conflicts of interest to disclose.
Data sharing statement: Technical data and information were provided by the corresponding author, Michael LeCompte who can be reached at michael_lecompte@med.unc.edu. Data from research subjects was anonymized and excluded any patient identifiers. Given the retrospective nature of this study, informed consent was deemed not necessary by the IRB. Additional data was collected and reviewed from datasets collected and published in the literature.
STROBE statement: The authors have read and revised the manuscript based on the STROBE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Michael T LeCompte, MD, Assistant Professor, Department of Surgical Oncology, University of North Carolina, 2800 Blue Ridge Rd. Suite 300, Raleigh, NC 27608, United States. mtleco01@gmail.com
Received: June 8, 2021
Peer-review started: June 8, 2021
First decision: June 27, 2021
Revised: July 11, 2021
Accepted: March 4, 2022
Article in press: March 4, 2022
Published online: April 14, 2022
Core Tip

Core Tip: This is a retrospective study that compares a single institution’s experience with that of a systematic literature review to evaluate the common clinical symptoms and presentation of heterotopic pancreas. To date, there have been numerous small volume studies in the literature reporting heterotopic pancreas. However, these studies predominantly report asymptomatic or incidental cases and there are few studies characterizing the symptomatic presentation of this disease. The goal of this study is to classify symptomatic cases of heterotopic pancreas to better identify the presentation and management of this disease.