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World J Gastroenterol. Mar 21, 2022; 28(11): 1102-1112
Published online Mar 21, 2022. doi: 10.3748/wjg.v28.i11.1102
Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship
Damiano D’Ardes, Andrea Boccatonda, Giulio Cocco, Stefano Fabiani, Ilaria Rossi, Marco Bucci, Maria Teresa Guagnano, Cosima Schiavone, Francesco Cipollone
Damiano D’Ardes, Ilaria Rossi, Marco Bucci, Maria Teresa Guagnano, Francesco Cipollone, “Clinica Medica” Institute, Department of Medicine and Aging Sciences, “G. D’Annunzio” University of Chieti-Pescara, Chieti 66100, Italy
Andrea Boccatonda, Giulio Cocco, Stefano Fabiani, Cosima Schiavone, Unit of Ultrasound, “G. D’Annunzio” University of Chieti-Pescara, Chieti 66100, Italy
Author contributions: All authors have designed, written and revised the manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with the authors of this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Damiano D’Ardes, MD, Doctor, Research Fellow, “Clinica Medica” Institute, Department of Medicine and Aging Sciences, “G. D’Annunzio” University of Chieti-Pescara, Chieti 66100, Italy. 89damiano@gmail.com
Received: April 18, 2021
Peer-review started: April 18, 2021
First decision: July 27, 2021
Revised: August 9, 2021
Accepted: February 15, 2022
Article in press: February 15, 2022
Published online: March 21, 2022
Processing time: 332 Days and 6.5 Hours
Core Tip

Core Tip: Evidence in the literature suggests a contribution of the severe acute respiratory syndrome coronavirus 2 to the pathophysiology of liver injury, atherothrombosis and coagulation disorders. This minireview explores the possible mechanisms by which these alterations are generated during coronavirus disease 2019 according to current knowledge.