Letter to the Editor
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2021; 27(45): 7859-7861
Published online Dec 7, 2021. doi: 10.3748/wjg.v27.i45.7859
Therapeutic potentials of fasudil in liver fibrosis
Yue Xi, Peng-Fei Xu
Yue Xi, Peng-Fei Xu, Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, United States
Author contributions: Xu PF designed the framework and supervised the preparation; both authors have wrote the letter, prepared the figures, read and approved the final letter.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng-Fei Xu, PhD, Academic Research, Postdoctoral Fellow, Research Associate, Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, 323 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA 15261, United States. pex9@pitt.edu
Received: July 4, 2021
Peer-review started: July 4, 2021
First decision: August 8, 2021
Revised: August 11, 2021
Accepted: November 24, 2021
Article in press: November 24, 2021
Published online: December 7, 2021
Processing time: 152 Days and 6.9 Hours
Core Tip

Core Tip: This letter to the editor is to supplement the ongoing discussion on the therapeutic potentials of Fasudil in the treatment of hepatic fibrosis. Fasudil is potential for the treatment of liver fibrosis through activating natural killer cells and inhibiting the proliferation of hepatic stellate cells. Fasudil, a vasodilator used in clinical treatment of cerebral vasospasm, exhibits the protective and therapeutic effect on liver fibrosis.