Clinical and Translational Research
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2021; 27(45): 7801-7812
Published online Dec 7, 2021. doi: 10.3748/wjg.v27.i45.7801
MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers
Ana Elisa Valencise Quaglio, Felipe Jose Santaella, Maria Aparecida Marchesan Rodrigues, Ligia Yukie Sassaki, Luiz Claudio Di Stasi
Ana Elisa Valencise Quaglio, Luiz Claudio Di Stasi, Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTec), Department of Biophysics and Pharmacology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu 18618-689, São Paulo, Brazil
Felipe Jose Santaella, Maria Aparecida Marchesan Rodrigues, Department of Pathology, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu 18618-687, São Paulo, Brazil
Ligia Yukie Sassaki, Department of Internal Medicine, Botucatu Medical School, São Paulo State University (Unesp), Botucatu 18618-687, São Paulo, Brazil
Author contributions: All authors contributed to this manuscript; Quaglio AEV, Rodrigues AMM, Sassaki LY and Di Stasi LC contributed to the conception of the study; Quaglio AEV and Santaella FJ did the acquisition; Di Stasi LC revised the manuscript critically for important intellectual content and submitted the final approval version; all authors contributed to the interpretation of data, drafting of the article and approved the final version of the article.
Supported by São Paulo Research Foundation (FAPESP) grants, No. 2017/03959-8 and No. 2015/15267-8.
Institutional review board statement: This study was approved by the Botucatu Medical School Research Ethics Committee, No. 71379417.2.0000.5411.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ana Elisa Valencise Quaglio, PhD, Professor, Research Scientist, Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTec), Department of Biophysics and Pharmacology, São Paulo State University (Unesp), Institute of Biosciences, R. Prof. Dr. Antônio Celso Wagner Zanin, 250-Distrito de Rubião Junior, Botucatu 18618-689, São Paulo, Brazil. anaequaglio@hotmail.com
Received: April 28, 2021
Peer-review started: April 28, 2021
First decision: June 13, 2021
Revised: June 14, 2021
Accepted: November 20, 2021
Article in press: November 20, 2021
Published online: December 7, 2021
Core Tip

Core Tip: This study identified 27 microRNAs (miRNAs) with significantly different expression levels between Crohn’s disease (CD) and ulcerative colitis (UC) patients. Five miRNAs whose expression levels were significantly lower in the UC patients than in the CD patients were selected for enrichment analysis, which revealed enrichment in certain signaling pathways that were mostly associated with cancer-related processes. The characterization and comparison of the differentially expressed miRNAs in this study could lead to novel diagnostic biomarkers to differentiate UC from CD. These markers might also predict prognosis, help elucidate the distinct pathophysiology of each disease, and lead to novel therapeutic target identification.