Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2021; 27(45): 7739-7747
Published online Dec 7, 2021. doi: 10.3748/wjg.v27.i45.7739
Published online Dec 7, 2021. doi: 10.3748/wjg.v27.i45.7739
Orosomucoid in liver diseases
Gulsum Ozlem Elpek, Department of Pathology, Akdeniz University Medical School, Antalya 07070, Turkey
Author contributions: Elpek GO performed the design of the article, obtained, analyzed and interpreted the data, and wrote the article.
Conflict-of-interest statement: There is not any conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gulsum Ozlem Elpek, MD, Professor, Research Assistant Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, Antalya 07070, Turkey. elpek@akdeniz.edu.tr
Received: March 15, 2021
Peer-review started: March 15, 2021
First decision: June 3, 2021
Revised: June 14, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 7, 2021
Peer-review started: March 15, 2021
First decision: June 3, 2021
Revised: June 14, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 7, 2021
Core Tip
Core Tip: Orosomucoid (ORM) has been suggested as a noninvasive marker in the diagnosis and follow-up of liver diseases. Currently, the results support the hypothesis that ORM can be used together with other markers to diagnose acute liver failure, monitor the development of cirrhosis, and detect early hepatocellular carcinoma (HCC). Although its role in carcinogenesis has not been entirely determined, the fact that decreased ORM2 expression is associated with carcinogenesis and poor prognosis warrants further study with the aim of better understanding the role of ORM in tumor behavior. The use of ORM expression to distinguish HCC from other neoplastic lesions and its role in differential diagnosis await investigation.