Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2021; 27(42): 7387-7401
Published online Nov 14, 2021. doi: 10.3748/wjg.v27.i42.7387
Long-term clinical outcomes of lipiodol marking using standard gastroscopy for image-guided radiotherapy of upper gastrointestinal cancers
Kim Hay Be, Richard Khor, Daryl Lim Joon, Ben Starvaggi, Michael Chao, Sweet Ping Ng, Michael Ng, Leonardo Zorron Cheng Tao Pu, Marios Efthymiou, Rhys Vaughan, Sujievvan Chandran
Kim Hay Be, Leonardo Zorron Cheng Tao Pu, Marios Efthymiou, Rhys Vaughan, Sujievvan Chandran, Department of Gastroenterology and Hepatology, Austin Health, Heidelberg 3084, Victoria, Australia
Richard Khor, Daryl Lim Joon, Ben Starvaggi, Michael Chao, Sweet Ping Ng, Department of Radiation Oncology, Austin Health, Heidelberg 3084, Victoria, Australia
Richard Khor, Sweet Ping Ng, School of Cancer Medicine, La Trobe University, Melbourne 3086, Victoria, Australia
Michael Chao, Sweet Ping Ng, Marios Efthymiou, Rhys Vaughan, Sujievvan Chandran, Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville 3010, Victoria, Australia
Michael Ng, Genesis Care, East Melbourne 3002, Victoria, Australia
Author contributions: Be KH, Zorron Cheng Tao Pu L, Khor R, Lim Joon D, Chandran S, Efthymiou M and Vaughan R conceptualized and designed the study; all authors were involved in data collection, analyses, or both; all authors were involved in the interpretation of the results; Be KH, Zorron Cheng Tao Pu L, Khor R and Chandran S drafted the manuscript; Lim Joon D, Ng SP, Efthymiou M and Vaughan R carried the critical revision of the article for important intellectual content; and all authors read and approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Austin Health Institutional Review Board (Approval No. LNR/18/Austin/254).
Informed consent statement: Informed consent was waived.
Conflict-of-interest statement: Dr. BE on behalf of all authors has nothing to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kim Hay Be, MBBS, Doctor, Department of Gastroenterology and Hepatology, Austin Health, 145 Studley Road, Heidelberg 3084, Victoria, Australia. kim.be@austin.org.au
Received: July 5, 2021
Peer-review started: July 5, 2021
First decision: July 13, 2021
Revised: July 26, 2021
Accepted: October 27, 2021
Article in press: October 27, 2021
Published online: November 14, 2021
Processing time: 128 Days and 5.2 Hours
Core Tip

Core Tip: Based on a cohort of 31 patients who had undergone lipiodol fiducial implantation through standard gastroscopy and received radiotherapy, fiducial-based image-guided radiotherapy (IGRT) was possible in 87.1%. Our cohort had an overall survival of 19 mo and progression-free survival of 13 mo. Further studies are warranted to determine the long-term outcomes of liquid-fiducial based IGRT.