Frontier
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2021; 27(41): 7014-7024
Published online Nov 7, 2021. doi: 10.3748/wjg.v27.i41.7014
Recent insights into the characteristics and role of peritoneal macrophages from ascites of cirrhotic patients
Pilar García-Peñarrubia, Antonio José Ruiz-Alcaraz, Miriam Ruiz-Ballester, Tamara Nadira Ramírez-Pávez, María Martínez-Esparza
Pilar García-Peñarrubia, Antonio José Ruiz-Alcaraz, Miriam Ruiz-Ballester, Tamara Nadira Ramírez-Pávez, María Martínez-Esparza, Department of Biochemistry and Molecular Biology B and Immunology, School of Medicine, University of Murcia, Murcia 30100, Spain
Author contributions: García-Peñarrubia P designed the overall concept outline of this manuscript and was responsible for writing, editing, reviewing the bibliography and approving the final version of the article; Ruiz-Alcaraz AJ wrote the manuscript, compiled, reviewed and edited the bibliography, adapted the figures and approved the final version of the article; Martínez-Esparza M wrote the manuscript, compiled and reviewed the bibliography and approved the final version of the article; Ruiz-Ballester M and Ramírez-Pávez TN meet the criteria for authorship established by the International Committee of Medical Journal Editors and approved the final version of the article.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pilar García-Peñarrubia, MD, PhD, Full Professor, Senior Researcher, Department of Biochemistry and Molecular Biology B and Immunology, School of Medicine, University of Murcia, Campus de Espinardo, Murcia 30100, Spain. pigarcia@um.es
Received: April 14, 2021
Peer-review started: April 14, 2021
First decision: June 23, 2021
Revised: July 2, 2021
Accepted: October 11, 2021
Article in press: October 11, 2021
Published online: November 7, 2021
Processing time: 205 Days and 10.9 Hours
Core Tip

Core Tip: This frontier article is based on a summary of recent relevant publications on the biology of mouse, as the main animal model used, and human peritoneal macrophages under the perspective of its future clinical translation to the role that these cells can play on several human liver diseases. Concretely, we have reviewed recent findings on several characteristics of human peritoneal macrophages obtained from the ascites of cirrhotic patients compared with those obtained from healthy donors. Featured article: Role of MAP kinases and PI3K-Akt on the cytokine inflammatory profile of peritoneal macrophages from the ascites of cirrhotic patients.