Wang MF, Wan B, Wu YL, Huang JF, Zhu YY, Li YB. Clinic-pathological features of metabolic associated fatty liver disease with hepatitis B virus infection. World J Gastroenterol 2021; 27(4): 336-344 [PMID: 33584066 DOI: 10.3748/wjg.v27.i4.336]
Corresponding Author of This Article
You-Bing Li, PhD, Associate Chief Physician, Department of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. liyoubing1976@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 28, 2021; 27(4): 336-344 Published online Jan 28, 2021. doi: 10.3748/wjg.v27.i4.336
Clinic-pathological features of metabolic associated fatty liver disease with hepatitis B virus infection
Ming-Fang Wang, Bo Wan, Yin-Lian Wu, Jiao-Feng Huang, Yue-Yong Zhu, You-Bing Li
Ming-Fang Wang, Department of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Bo Wan, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
Yin-Lian Wu, Jiao-Feng Huang, Yue-Yong Zhu, You-Bing Li, Department ofLiver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Author contributions: Wang MF and Li YB designed the study; Huang JF and Wu YL collected and analyzed the data; Wang MF and Wan B drafted the manuscript; Zhu YY and Li YB critically revised the manuscript; Wang MF and Wan B contributed equally to this work; all authors approved the final version of the manuscript prior to submission.
Supported byChinese National 13th Five-Year Plan's Science and Technology Projects, No. 2017ZX10202201.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Fujian Medical University in accordance with the Declaration of Helsinki.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: You-Bing Li, PhD, Associate Chief Physician, Department of Liver Research Center, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. liyoubing1976@sina.com
Received: October 9, 2020 Peer-review started: October 9, 2020 First decision: December 3, 2020 Revised: December 11, 2020 Accepted: December 22, 2020 Article in press: December 22, 2020 Published online: January 28, 2021 Processing time: 107 Days and 15.1 Hours
Core Tip
Core Tip: Metabolic associated fatty liver disease (MAFLD) is a novel concept proposed in 2020 aiming to replace the previous definition of non-alcoholic fatty liver disease. Patients with MAFLD have different features from those with non-alcoholic fatty liver disease because MAFLD does not require the exclusion of other chronic liver disease, such as hepatitis B virus (HBV) infection. In this study, we compared the characteristics of patients with and without HBV infection in a biopsy-proved MAFLD cohort. The results of this study involving 417 participants showed that cases with HBV-MAFLD had similar metabolic features as pure MAFLD, and the presence of HBV infection was associated with lower steatosis grade but higher inflammation and fibrosis grade in MAFLD. These results highlight the importance of the monitoring and managing HBV infection in MAFLD.
