Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2021; 27(36): 6079-6092
Published online Sep 28, 2021. doi: 10.3748/wjg.v27.i36.6079
Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells
Hai-Yan Cui, Jian-Sheng Rong, Ju Chen, Jie Guo, Jia-Qin Zhu, Mei Ruan, Rong-Rong Zuo, Shuang-Shuang Zhang, Jun-Mei Qi, Bao-Hua Zhang
Hai-Yan Cui, Rong-Rong Zuo, Shuang-Shuang Zhang, Jun-Mei Qi, Department of Pathology, The Fourth People’s Hospital of Zibo City, Zibo 255000, Shandong Province, China
Jian-Sheng Rong, Bao-Hua Zhang, Department of Pathology, Zibo Central Hospital, Zibo 255036, Shandong Province, China
Ju Chen, Department of Ultrasound Medicine, Zibo Central Hospital, Zibo 255036, Shandong Province, China
Jie Guo, Department of Health, The Fourth People’s Hospital of Zibo City, Zibo 255000, Shandong Province, China
Jia-Qin Zhu, Department of Gastroenterology, The Fourth People’s Hospital of Zibo City, Zibo 255000, Shandong Province, China
Mei Ruan, Department of Oncology, The Fourth People’s Hospital of Zibo City, Zibo 255000, Shandong Province, China
Author contributions: Cui HY, Rong JS, and Chen J designed the study; Guo J, Zhu JQ, and Ruan M performed the experiments; Zuo RR and Zhang SS collected and analysed the data; Qi JM and Zhang BH wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Zibo Central Hospital.
Institutional animal care and use committee statement: All animal experiments in this study were approved by the Zibo Central Hospital.
Conflict-of-interest statement: The authors declare no conflict of interest for this manuscript.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Hua Zhang, MSc, Chief Physician, Department of Pathology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zhangdian District, Zibo 255036, Shandong Province, China. zhangbaohua314@163.com
Received: April 23, 2021
Peer-review started: April 23, 2021
First decision: May 27, 2021
Revised: June 7, 2021
Accepted: August 11, 2021
Article in press: August 11, 2021
Published online: September 28, 2021
Processing time: 152 Days and 17.8 Hours
Core Tip

Core Tip: In this study, we uncovered that exosomal miR-588 from M2 macrophages contributes to cisplatin resistance of gastric cancer cells by partly targeting cylindromatosis. miR-588 may be applied as a potential therapeutic target for the treatment of gastric cancer.