Liu F, Xiao XL, Liu YJ, Xu RH, Zhou WJ, Xu HC, Zhao AG, Xu YX, Dang YQ, Ji G. CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis. World J Gastroenterol 2021; 27(36): 6064-6078 [PMID: 34629820 DOI: 10.3748/wjg.v27.i36.6064]
Corresponding Author of This Article
Guang Ji, MD, PhD, Professor, Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feng Liu, Xiao-Li Xiao, Yu-Jing Liu, Ruo-Hui Xu, Wen-Jun Zhou, Han-Chen Xu, Yan-Qi Dang, Guang Ji, Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Feng Liu, Ai-Guang Zhao, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Yang-Xian Xu, Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Liu F and Xiao XL contributed equally to this work. Ji G and Dang YQ should be regarded as co-corresponding authors; Ji G and Dang YQ conceived, designed, and supervised the study; Dang YQ, Xu YX, and Xu HC collected the samples; Liu F, Xiao XL, Liu YJ, and Xu RH performed the experiments; Dang YQ, Liu F, and Zhou WJ analyzed the data; Dang YQ and Liu F wrote the paper; Zhou WJ, Zhao AG, and Ji G revised the manuscript; all authors reviewed and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 81804018 and No. 81874206; and the Key Project of the Shanghai 3-Year Plan, No. ZY[2018-2020]CCCX-2002-01.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (No. 2019LCSY020).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The original data of this study will be available upon request from corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang Ji, MD, PhD, Professor, Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases (ccCRDD), Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com
Received: March 3, 2021 Peer-review started: March 3, 2021 First decision: June 3, 2021 Revised: June 4, 2021 Accepted: August 9, 2021 Article in press: August 9, 2021 Published online: September 28, 2021 Processing time: 203 Days and 23.4 Hours
Core Tip
Core Tip: The 5-year survival rate of patients with early-stage colorectal cancer (CRC) could reach 90%, but it is very low in patients with advanced-stage CRC. Recent studies have shown that circular RNAs play important roles in regulating the migration and invasion of CRC cells. To elucidate the role of circRNA_0084927 (circ_0084927) in the migration and invasion of CRC cells and the underlying mechanism, this study was performed. The expression of circ_0084927 was significantly increased in CRC tissues and cells, and it was markedly higher in advanced-stage CRC compared with early-stage CRC. Knockdown of circ_0084927 inhibited the migration and invasion of HCT116 cells. Moreover, circ_0084927 potentially regulates CRC migration and invasion via the miRNA-20b-3p/glutathione S-transferase mu 5 pathway.
