Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2021; 27(36): 6004-6024
Published online Sep 28, 2021. doi: 10.3748/wjg.v27.i36.6004
Histone methylation in pancreatic cancer and its clinical implications
Xing-Yu Liu, Chuan-Hao Guo, Zhi-Yuan Xi, Xin-Qi Xu, Qing-Yang Zhao, Li-Sha Li, Ying Wang
Xing-Yu Liu, Xin-Qi Xu, Qing-Yang Zhao, Ying Wang, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin Province, China
Chuan-Hao Guo, Zhi-Yuan Xi, Li-Sha Li, The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Liu XY, Guo CH, Xi ZY, Xu XQ, and Zhao QY drafted the manuscript and designed the tables; Li LS and Wang Y designed and revised the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflicts of interests or financial disclosures relevant to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Ying Wang, MM, Technologist-In-Charge, The First Hospital of Jilin University, Jilin University, No. 126 Xinmin Street, Changchun 130021, Jilin Province, China.
Received: January 27, 2021
Peer-review started: January 27, 2021
First decision: February 25, 2021
Revised: March 12, 2021
Accepted: April 22, 2021
Article in press: April 22, 2021
Published online: September 28, 2021
Core Tip

Core Tip: Pancreatic cancer is a highly lethal malignancy of the digestive tract that is difficult to diagnose and treat. Histone methylation/demethylation equilibrium is altered in carcinogenesis, resulting in changes in chromatin structure and gene expression. Not only are histone methylation writers related to histone methylation erasers but histone methylation is also related to other epigenetic modifications. Therefore, histone methylation is addressed as a potentially important chemotherapy drug target.