Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2021; 27(34): 5764-5774
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5764
Secular decreasing trends in gastric cancer incidence in Taiwan: A population-based cancer registry study
Yen-Tzeng Lin, Chun-Ju Chiang, Ya-Wen Yang, Shih-Pei Huang, San-Lin You
Yen-Tzeng Lin, School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242008, Taiwan
Chun-Ju Chiang, Ya-Wen Yang, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10617, Taiwan
Shih-Pei Huang, Department of Medical Education & Bioethics, Graduate Institute of Medical Education & Bioethics, National Taiwan University College of Medicine, Taipei 10051, Taiwan
San-Lin You, School of Medicine & Big Data Research Center, Fu Jen Catholic University, New Taipei City 242008, Taiwan
Author contributions: Lin YT, Huang SP, and You SL conceived and designed the study; Chiang CJ and You SL acquired the data; Lin YT and Yang YW performed the data analyses; Lin YT, Huang SP, and You SL drafted the manuscript; Lin YT, Huang SP, and You SL assisted in interpretation of the data; Lin YT, Chiang CJ, Yang YW, Huang SP, and You SL critically revised the manuscript for intellectual content.
Institutional review board statement: The study was reviewed and approved by the Fu Jen Catholic University Institutional Review Board.
Informed consent statement: This research protocol was approved by the Institutional Review Board of Fu-Jen Catholic University (C107034).
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shih-Pei Huang, MD, PhD, Adjunct Assistant Professor, Doctor, Department of Medical Education & Bioethics, Graduate Institute of Medical Education & Bioethics, National Taiwan University College of Medicine, No. 1 Jen Ai Road, Section 1, Taipei 10051, Taiwan. esphuang.imbd@gmail.com
Received: March 23, 2021
Peer-review started: March 23, 2021
First decision: April 29, 2021
Revised: May 11, 2021
Accepted: August 6, 2021
Article in press: August 6, 2021
Published online: September 14, 2021
Processing time: 169 Days and 16.2 Hours
Core Tip

Core Tip: Gastric cancer remains a leading cause of cancer death worldwide. In this population-based study, we used the national Taiwan Cancer Registry database to evaluate secular trends in gastric cancer incidence in Taiwan. Annual percent changes showed continuously decreasing rates of gastric cancer among both males and females, with an annual percent change of -2.58% in males and -2.14% in females. Age-specific incidence rates increased with age. Within the same age group, the sex ratio was lower in later birth cohorts than in earlier birth cohorts. Age-adjusted incidence rates substantially decreased with the increase in patients newly treated with anti-Helicobacter pylori treatment.