Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2021; 27(34): 5666-5681
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5666
Recent advances in blood-based and artificial intelligence-enhanced approaches for gastrointestinal cancer diagnosis
Li-Shi Li, Xiang-Yu Guo, Kun Sun
Li-Shi Li, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen 518055, Guangdong Province, China
Li-Shi Li, Xiang-Yu Guo, Kun Sun, Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518132, Guangdong Province, China
Kun Sun, BGI-Shenzhen, Shenzhen 518083, Guangdong Province, China
Author contributions: Sun K outlined the article; Li LS and Guo XY performed the literature review and wrote the paper; Sun K revised the manuscript critically for important intellectual content and approved the final version for submission.
Supported by Guangdong Basic and Applied Basic Research Foundation, No. 2019A1515110173; BGI-research, No. BGIRSZ2020007; and Shenzhen Bay Laboratory.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Kun Sun, PhD, Assistant Professor, Institute of Cancer Research, Shenzhen Bay Laboratory, Rm B302, Guangming International Innovation Center, Guangming District, Shenzhen 518132, Guangdong Province, China.
Received: January 27, 2021
Peer-review started: January 27, 2021
First decision: May 2, 2021
Revised: May 14, 2021
Accepted: August 3, 2021
Article in press: August 3, 2021
Published online: September 14, 2021
Core Tip

Core Tip: Recent studies have discovered a variety of blood-based biomarkers with great potential in improving the diagnosis and surveillance of gastrointestinal (GI) cancers. In this article, we review the latest advances in the diagnosis of various GI cancers, focusing on emerging blood-based liquid biopsy assays and artificial intelligence-enhanced approaches. We also discuss purity assessment approaches for tissue biopsies, which is an important issue in cancer studies, especially those applicable in metastatic GI cancers.