Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2021; 27(33): 5566-5574
Published online Sep 7, 2021. doi: 10.3748/wjg.v27.i33.5566
Adiponectin and the regulation of gastric content volume in the newborn rat
Huanhuan Wang, Paul Esemu-Ezewu, Jingyi Pan, Julijana Ivanovska, Estelle B Gauda, Jaques Belik
Huanhuan Wang, Paul Esemu-Ezewu, Jingyi Pan, Julijana Ivanovska, Estelle B Gauda, Department of Paediatrics, The Hospital for Sick Children, Toronto M5G 1X8, Ontario, Canada
Jaques Belik, Department of Paediatrics and Physiology, The Hospital for Sick Children, Toronto M5G 1X8, Ontario, Canada
Author contributions: Wang H, Esemu-Ezewu P, Pan J and Ivanovska J performed the experiments, acquired and analyzed the data and contributed to drafting the manuscript; Gauda EB and Belik J designed, coordinated the study and finalized the manuscript.
Supported by Canadian Institutes of Health Research, No. CIA310955.
Institutional animal care and use committee statement: All procedures were conducted in accordance with the Canadian Animals for Research Act and Canadian Council on Animal Care regulations, and the Hospital for Sick Children Research Institute Animal Care Committee approved the study, No. 1000046424.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at jaques.belik@sickkids.ca.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jaques Belik, FRCP (C), MD, Professor, Department of Paediatrics and Physiology, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Ontario, Canada. jaques.belik@sickkids.ca
Received: March 9, 2021
Peer-review started: March 9, 2021
First decision: May 1, 2021
Revised: May 12, 2021
Accepted: August 12, 2021
Article in press: August 12, 2021
Published online: September 7, 2021
Processing time: 178 Days and 10.8 Hours
Core Tip

Core Tip: Gastric accommodation regulates the stomach content volume. Lactating rats continuously breastfeed to keep a full gastric milk volume and their gastric emptying time is directly related to the gastric content volume. Little is known about the gastric fundic accommodation regulatory factors early in life. In this study, breastmilk-derived adiponectin is shown to promote gastric fundic relaxation, thus playing an important regulatory role during the lactating period.