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World J Gastroenterol. Sep 7, 2021; 27(33): 5555-5565
Published online Sep 7, 2021. doi: 10.3748/wjg.v27.i33.5555
Gut microbiota-derived metabolites as key mucosal barrier modulators in obesity
Yan-Xia Wei, Kui-Yang Zheng, Yu-Gang Wang
Yan-Xia Wei, Kui-Yang Zheng, Yu-Gang Wang, Laboratory of Infection and Immunity, Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
Author contributions: Wei Y performed the majority of the writing; Zheng K provided input in writing the paper; Wang Y provided input in writing the paper, designed the outline and coordinated the writing of the paper and prepared the figures.
Supported by The National Natural Science Foundation of China, No. 81770853 and No. 81970730.
Conflict-of-interest statement: There are no conflicts of interest associated with any of the senior authors or other coauthors who contributed to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Gang Wang, PhD, Professor, Laboratory of Infection and Immunity, Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, No. 209 Tongshan Road, Xuzhou 221004, Jiangsu Province, China. wangyg@xzhmu.edu.cn
Received: March 1, 2021
Peer-review started: March 1, 2021
First decision: April 17, 2021
Revised: April 24, 2021
Accepted: July 23, 2021
Article in press: July 23, 2021
Published online: September 7, 2021
Processing time: 185 Days and 17.7 Hours
Core Tip

Core Tip: The manner in which the gut microbiota influences obesity development remains incompletely understood. Recent studies have indicated that the changes in the gut barrier functions act as an important driver of metabolic disorders. There is currently an urgent need to define molecular and cellular modulators of intestinal mucosal barrier homeostasis. Here, we discuss the current understanding of microbiota-derived metabolites in regulating mucosal homeostasis and how they contribute to the metabolic health of the host.