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World J Gastroenterol. Sep 7, 2021; 27(33): 5536-5554
Published online Sep 7, 2021. doi: 10.3748/wjg.v27.i33.5536
Surveillance for hepatocellular carcinoma in chronic viral hepatitis: Is it time to personalize it?
Coskun Ozer Demirtas, Maurizia Rossana Brunetto
Coskun Ozer Demirtas, Department of Gastroenterology and Hepatology, Marmara University, School of Medicine, Istanbul 34854, Turkey
Maurizia Rossana Brunetto, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa 56125, Italy
Maurizia Rossana Brunetto, Hepatology Unit, University Hospital of Pisa, Pisa 56125, Italy
Maurizia Rossana Brunetto, Biostructure and Bio-imaging Institute, National Research Council of Italy, Naples 56125, Italy
Author contributions: Demirtas CO performed the literature search and wrote the paper; Brunetto MR critically revised the manuscript; All authors approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Coskun Ozer Demirtas, MD, Postdoctoral Fellow, Department of Gastroenterology and Hepatology, Marmara University, School of Medicine, Marmara Üniversitesi Göztepe Yerleşkesi, Istanbul 34854, Turkey. coskun_demirtas10@hotmail.com
Received: February 11, 2021
Peer-review started: February 11, 2021
First decision: April 18, 2021
Revised: April 28, 2021
Accepted: August 2, 2021
Article in press: August 2, 2021
Published online: September 7, 2021
Processing time: 203 Days and 23.6 Hours
Core Tip

Core Tip: The risk of hepatocellular carcinoma (HCC) is not uniform and may increase due to underlying parameters in chronic viral hepatitis. Several clinical HCC risk scores and biomarker integrated algorithms have been proposed to stratify patients according to their HCC risk level. In the present review, we summarize the efforts for personalized HCC surveillance in the literature and discuss their applicability to clinical practice.