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World J Gastroenterol. Aug 28, 2021; 27(32): 5362-5375
Published online Aug 28, 2021. doi: 10.3748/wjg.v27.i32.5362
Faecal microbiota transplantation enhances efficacy of immune checkpoint inhibitors therapy against cancer
Yong-Bo Kang, Yue Cai
Yong-Bo Kang, Yue Cai, Department of Microbiology and Immunology, School of Basic Medical Sciences, Shanxi Medical University, Jinzhong 030600, Shanxi Province, China
Author contributions: Kang YB collected the data and wrote most of the manuscript with help from Cai Y; Kang YB and Cai Y contributed equally to this study.
Supported by Science Research Start-up Fund for Doctor of Shanxi Medical University, No. XD1807; Science Research Start-up Fund for Doctor of Shanxi Province, No. SD1807; Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi, No. 2019L0425; and Shanxi Province Science Foundation for Youths, No. 201901D211314.
Conflict-of-interest statement: The authors report no conflicts of interest relevant to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Bo Kang, PhD, Associate Professor, Department of Microbiology and Immunology, School of Basic Medical Sciences, Shanxi Medical University, Zhongdu Campus, Yuci District, Jinzhong 030600, Shanxi Province, China. 657151276@qq.com
Received: March 2, 2021
Peer-review started: March 2, 2021
First decision: June 3, 2021
Revised: July 3, 2021
Accepted: July 12, 2021
Article in press: July 12, 2021
Published online: August 28, 2021
Processing time: 175 Days and 18.3 Hours
Core Tip

Core Tip: Gut microbiota composition is closely associated with the efficacy of immune checkpoint inhibitors (ICIs). Specific species among the intestinal commensal bacteria may play a key role in the efficacy of ICIs against cancer. Faecal microbiota transplantation may enhance efficacy of ICIs.