Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2021; 27(31): 5272-5287
Published online Aug 21, 2021. doi: 10.3748/wjg.v27.i31.5272
Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program
Christian Balamou, Akoï Koïvogui, Christelle M Rodrigue, Aurélie Clerc, Claire Piccotti, Anne Deloraine, Catherine Exbrayat
Christian Balamou, Christelle M Rodrigue, Site de l'Ain, Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-Alpes, Bourg-en-Bresse 01000, France
Akoï Koïvogui, Site de Seine-Saint-Denis, Centre Régional de Coordination des Dépistages des Cancers en Ile-de-France, Bondy 93146, France
Aurélie Clerc, Anne Deloraine, Sites Savoie & Haute Savoie, Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-Alpes, Chambéry 73000, France
Claire Piccotti, Site de Drôme Ardèche, Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-Alpes, Valence 26000, France
Catherine Exbrayat, Site Isère & Drôme-Ardèche, Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-Alpes, Meylan 38240, France
Author contributions: The study was conceived and designed by Balamou C and Koïvogui A; the data was acquired and collated by Balamou C, Clerc A, Piccotti C, Deloraine A, and Exbrayat C; the data were analyzed by Balamou C, Koïvogui A, and Rodrigue CM; the study was drafted and revised critically by all authors; All authors gave final approval of the version to be published and have contributed to the study.
Institutional review board statement: This study is co-signed by the heads of the structures involved, as such, no further Institutional Review Board was required.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that was obtained after each patient agreed to participate in screening campaigns.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Data and materials are available when requested by e-mail. However, each request will be processed in accordance with French legislation on the availability of research data.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christian Balamou, MD, MHSc, MSc, Doctor, Site de l'Ain, Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-Alpes, 58 rue Robespierre, Bourg-en-Bresse 01000, France. cbalamou@yahoo.fr
Received: February 12, 2021
Peer-review started: February 12, 2021
First decision: April 18, 2021
Revised: May 3, 2021
Accepted: July 20, 2021
Article in press: July 20, 2021
Published online: August 21, 2021
Core Tip

Core Tip: The study showed that the severity of the colonic lesions increases with a high concentration of fecal hemoglobin measured in previous test. The elderly (≥ 70 years) had a high proportion of positive colonoscopy when the fecal hemoglobin concentration measured in previous campaign was between 100 and 150 ngHb/mL. Younger patients (age < 54) were likely to have a high-severity neoplasia. Given these results, the recommendation to reduce the FIT positivity threshold to 100 ngHb/mL for first-time participants and the elderly (aged ≥ 70) should attract the attention of the decision-making authority.