Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2021; 27(29): 4846-4861
Published online Aug 7, 2021. doi: 10.3748/wjg.v27.i29.4846
Published online Aug 7, 2021. doi: 10.3748/wjg.v27.i29.4846
Neurological and psychiatric effects of hepatitis C virus infection
Jessica Faccioli, Silvia Nardelli, Stefania Gioia, Oliviero Riggio, Lorenzo Ridola, Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome 00185, Italy
Author contributions: Faccioli J and Ridola L drafted the manuscript; Nardelli S, Gioia S, Riggio O and Ridola L critically reviewed the manuscript for important intellectual content; Riggio O and Ridola L approved the manuscript.
Conflict-of-interest statement: None declared.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lorenzo Ridola, MD, PhD, Associate Professor, Department of Translational and Precision Medicine, “Sapienza” University of Rome, viale dell’ Università, 37, Rome 00185, Italy. lorenzo.ridola@uniroma1.it
Received: February 2, 2021
Peer-review started: February 2, 2021
First decision: May 1, 2021
Revised: May 7, 2021
Accepted: June 4, 2021
Article in press: June 4, 2021
Published online: August 7, 2021
Peer-review started: February 2, 2021
First decision: May 1, 2021
Revised: May 7, 2021
Accepted: June 4, 2021
Article in press: June 4, 2021
Published online: August 7, 2021
Core Tip
Core Tip: The aim of this review is to provide a critical overview of neurological and psychiatric disorders in patients with hepatitis C virus infection, the underlying pathogenetic mechanisms and the effect of new direct-acting antivirals on extrahepatic symptoms. The main clinical and pathogenetic differences to hepatic encephalopathy and the different diagnostic strategies used in these two conditions are reported.