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World J Gastroenterol. Aug 7, 2021; 27(29): 4846-4861
Published online Aug 7, 2021. doi: 10.3748/wjg.v27.i29.4846
Neurological and psychiatric effects of hepatitis C virus infection
Jessica Faccioli, Silvia Nardelli, Stefania Gioia, Oliviero Riggio, Lorenzo Ridola
Jessica Faccioli, Silvia Nardelli, Stefania Gioia, Oliviero Riggio, Lorenzo Ridola, Department of Translational and Precision Medicine, “Sapienza” University of Rome, Rome 00185, Italy
Author contributions: Faccioli J and Ridola L drafted the manuscript; Nardelli S, Gioia S, Riggio O and Ridola L critically reviewed the manuscript for important intellectual content; Riggio O and Ridola L approved the manuscript.
Conflict-of-interest statement: None declared.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lorenzo Ridola, MD, PhD, Associate Professor, Department of Translational and Precision Medicine, “Sapienza” University of Rome, viale dell’ Università, 37, Rome 00185, Italy. lorenzo.ridola@uniroma1.it
Received: February 2, 2021
Peer-review started: February 2, 2021
First decision: May 1, 2021
Revised: May 7, 2021
Accepted: June 4, 2021
Article in press: June 4, 2021
Published online: August 7, 2021
Processing time: 182 Days and 13 Hours
Core Tip

Core Tip: The aim of this review is to provide a critical overview of neurological and psychiatric disorders in patients with hepatitis C virus infection, the underlying pathogenetic mechanisms and the effect of new direct-acting antivirals on extrahepatic symptoms. The main clinical and pathogenetic differences to hepatic encephalopathy and the different diagnostic strategies used in these two conditions are reported.