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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2021; 27(25): 3913-3924
Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3913
Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3913
Effect of gastric microbiota on quadruple Helicobacter pylori eradication therapy containing bismuth
Zhan-Yue Niu, Si-Zhu Li, Yan Xue, Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
Yan-Yan Shi, Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China
Author contributions: Xue Y was the guarantor and designed the study; Niu ZY, Li SZ and Shi YY participated in the acquisition, analysis, and interpretation of the data and drafted the initial manuscript; Xue Y revised the article critically for important intellectual content; all authors have read and approved the final manuscript.
Supported by The Key Projects of Peking University Third Hospital , No. BYSY2017026 .
Institutional review board statement: The study was reviewed and approved by the Peking University Third Hospital Medical Science Research Ethics Committee Institutional Review Board (Approval No. M2017389).
Informed consent statement: Informed written consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Xue, MD, Doctor, Department of Gastroenterology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. xueyanby@163.com
Received: February 9, 2021
Peer-review started: February 9, 2021
First decision: March 28, 2021
Revised: April 10, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: July 7, 2021
Processing time: 146 Days and 20.9 Hours
Peer-review started: February 9, 2021
First decision: March 28, 2021
Revised: April 10, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: July 7, 2021
Processing time: 146 Days and 20.9 Hours
Core Tip
Core Tip: Helicobacter pylori (H. pylori) is an important pathogen that can cause a variety of diseases. Its eradication can be affected by many factors. In this study, we explored the effect of the gastric microbiota on quadruple H. pylori eradication therapy containing bismuth. The results indicated that quadruple H. pylori eradication therapy containing bismuth was affected by the gastric microbiota. A high rate of H. pylori eradication was associated with the presence of Rhodococcus, Lactobacillus, and Sphingomonas. Our findings may provide the basis for clinical treatment.