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World J Gastroenterol. Jul 7, 2021; 27(25): 3815-3824
Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3815
Advances in paediatric nonalcoholic fatty liver disease: Role of lipidomics
Anna Di Sessa, Simona Riccio, Emilia Pirozzi, Martina Verde, Antonio Paride Passaro, Giuseppina Rosaria Umano, Stefano Guarino, Emanuele Miraglia del Giudice, Pierluigi Marzuillo
Anna Di Sessa, Simona Riccio, Emilia Pirozzi, Martina Verde, Antonio Paride Passaro, Giuseppina Rosaria Umano, Stefano Guarino, Emanuele Miraglia del Giudice, Pierluigi Marzuillo, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy
Author contributions: Di Sessa A wrote the manuscript; Miraglia del Giudice E, Di Sessa A, and Marzuillo P conceived the manuscript; Guarino S, Miraglia del Giudice E, and Marzuillo P supervised the manuscript drafting; Riccio S, Passaro AP, Verde M, Pirozzi E, and Umano GR reviewed the literature data; Riccio S prepared the tables; all author contributed important intellectual content during manuscript drafting or revision.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pierluigi Marzuillo, MD, PhD, Associate Professor, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Via de Crecchio 4, Naples 80138, Italy. pierluigi.marzuillo@gmail.com
Received: January 27, 2021
Peer-review started: January 27, 2021
First decision: March 29, 2021
Revised: April 6, 2021
Accepted: June 4, 2021
Article in press: June 4, 2021
Published online: July 7, 2021
Processing time: 159 Days and 3.8 Hours
Core Tip

Core Tip: Insightful data from lipidomics studies have recently expanded knowledge about nonalcoholic fatty liver disease pathophysiology. In fact, different lipids have been found to exert specific pathogenic roles in liver injury through several pathways (in particular by impairing insulin signalling). Given the cardiometabolic burden of nonalcoholic fatty liver disease even in childhood, lipidomics findings might improve strategies for nonalcoholic fatty liver disease treatment by providing novel therapeutic targets.