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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2021; 27(24): 3516-3529
Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3516
Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3516
Neuropilin-1: A feasible link between liver pathologies and COVID-19
Aitor Benedicto, Beatriz Arteta, Department of Cellular Biology and Histology, School of Medicine and Nursing, University of the Basque Country, Leioa 48940, Bizkaia, Spain
Iñigo García-Kamiruaga, Department of Gastroenterology and Hepatology, San Eloy Hospital, Barakaldo 48902, Spain
Author contributions: Benedicto A and Arteta B designed the review concept; Benedicto A, García-Kamiruaga and Arteta B wrote the manuscript.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Aitor Benedicto, PhD, Assistant Lecturer, Doctor, Department of Cellular Biology and Histology, School of Medicine and Nursing, University of the Basque Country, Barrio Sarriena s/n, Leioa 48940, Bizkaia, Spain. aitor.benedicto@ehu.es
Received: February 28, 2021
Peer-review started: February 28, 2021
First decision: March 27, 2021
Revised: April 16, 2021
Accepted: May 25, 2021
Article in press: May 25, 2021
Published online: June 28, 2021
Processing time: 116 Days and 12.8 Hours
Peer-review started: February 28, 2021
First decision: March 27, 2021
Revised: April 16, 2021
Accepted: May 25, 2021
Article in press: May 25, 2021
Published online: June 28, 2021
Processing time: 116 Days and 12.8 Hours
Core Tip
Core Tip: Severe acute respiratory syndrome coronavirus 2 uses angiotensin-converting enzyme 2 and neuropilin-1 (NRP-1) receptors to infect cells. NRP-1 expression is upregulated in several liver pathologies, which may facilitate viral infection. Moreover, the cytokine storm might increase liver permeability and NRP-1 expression, giving rise to an increased severity of infection and a worse prognosis.