Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2021; 27(23): 3372-3385
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3372
Effect of type 2 diabetic mellitus in the prognosis of acute-on-chronic liver failure patients in China
Rui-Min Lai, Tian-Bin Chen, Yu-Hai Hu, Gui Wu, Qi Zheng
Rui-Min Lai, Yu-Hai Hu, Qi Zheng, Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian Province, China
Tian-Bin Chen, Department of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian Province, China
Gui Wu, Department of Orthopedics, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian Province, China
Author contributions: Lai RM and Chen TB contributed equally to this work; Lai RM, Chen TB, and Zheng Q conceived and designed the study; Chen TB analyzed the data; Hu YH and Wu G collected clinical data of the patients; Lai RM and Zheng Q wrote the manuscript; all authors read and approved the final version of the manuscript.
Supported by Fujian Health Research Talents Training Program, No. 2019-1-42; National Natural Science Foundation of China, No. 81702073; and Fujian Provincial Natural Science Foundation General Project, No. 2020J01955.
Institutional review board statement: This study was approved by the Institutional Review Board of Fujian Medical University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at bei0825@163.com.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi Zheng, PhD, Professor, Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. bei0825@163.com
Received: January 28, 2021
Peer-review started: January 28, 2021
First decision: April 5, 2021
Revised: April 14, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: June 21, 2021
Processing time: 140 Days and 18.4 Hours
Core Tip

Core Tip: This study evaluated the association between type 2 diabetic mellitus (DM) and the prognosis of acute-on-chronic liver failure (ACLF) patients. The 222 ACLF patients were categorized into two groups depending on whether they had DM or not. Values of laboratory parameters, complication rates, and hospital mortality rates were compared between two groups. We observed a significant association between DM and the prognosis of ACLF patients in the study. The ACLF patients with DM had higher incidence of hospital mortality and infection than those without DM.