Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2021; 27(23): 3342-3356
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3342
Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice
Seunghun Lee, Jeonghoon Heo, Eun-Kyung Ahn, Jae Hyun Kim, Young-Ho Kim, Hee-Kyung Chang, Sang-Joon Lee, Jongsik Kim, Seun-Ja Park
Seunghun Lee, Department of Colorectal Surgery, Kosin University College of Medicine, Busan 49267, South Korea
Jeonghoon Heo, Eun-Kyung Ahn, Young-Ho Kim, Department of Molecular Biology and Immunology, Kosin University College of Medicine, Busan 49267, South Korea
Jae Hyun Kim, Seun-Ja Park, Department of Gastroenterology, Kosin University College of Medicine, Busan 49267, South Korea
Hee-Kyung Chang, Department of Pathology, Kosin University College of Medicine, Busan 49267, South Korea
Sang-Joon Lee, Department of Ophthalmology, Kosin University College of Medicine, Busan 49267, South Korea
Jongsik Kim, Department of Anatomy, Kosin University College of Medicine, Busan 49267, South Korea
Author contributions: Lee S, Ahn EK, Park SJ and Heo J designed the study; Lee S, Ahn EK, Chang HK, Kim J, Park SJ and Heo J performed the research; Lee S, Ahn EK, Kim JH, Kim YH, Lee SJ, Park SJ and Heo J participated in the interpretation of the data; Lee S, Ahn EK, Park SJ and Heo J wrote paper; Chang HK, Kim YH, Lee SJ, Kim J, Park SJ and Heo J supervised the analysis; all authors approved the final version.
Supported by National Research Foundation of Korea (NRF) grants funded by the Korea Government (MSIT), No. 2017R1A2B2011956 and No. 2019R1F1A1061453.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee at Kosin University College of Medicine (IACUC protocol number: Kosin15-12).
Conflict-of-interest statement: None of the authors have any conflicts of interest to declare.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seun-Ja Park, MD, PhD, Professor, Department of Gastroenterology, Kosin University College of Medicine, 262 Gamcheon-ro, Seogu, Busan 49267, South Korea. parksj@kosinmed.or.kr
Received: February 4, 2021
Peer-review started: February 4, 2021
First decision: February 24, 2021
Revised: March 5, 2021
Accepted: May 19, 2021
Article in press: May 19, 2021
Published online: June 21, 2021
Core Tip

Core Tip: The therapeutic ability of mesenchymal stem cells (MSCs) is mostly mediated by their paracrine effects. Cell free therapy using MSCs secretome could be more promising strategy than stem cells based therapy. The present study demonstrates that the conditioned secretome of adipose–derived stem cells (ADSCs) has more efficient effects for improving acute colitis in dextran sulfate-sodium-induced mouse model. The effects by the conditioned secretome of ADSCs were mediated by suppression of interleukin (IL)-6 mRNA synthesis in colon tissue and serum IL-6 protein levels, which suggests that the stem cell secretome may have efficient therapeutic potential for incurable inflammatory bowel diseases.