Calitri C, Fumi I, Ignaccolo MG, Banino E, Benetti S, Lupica MM, Fantone F, Pace M, Garofalo F. Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review. World J Gastroenterol 2021; 27(23): 3303-3316 [PMID: 34163113 DOI: 10.3748/wjg.v27.i23.3303]
Corresponding Author of This Article
Carmelina Calitri, MD, Doctor, Department of Paediatrics, Infermi Hospital, ASLTO3, Via Rivalta 29, Rivoli 10098, Italy. carmelina_calitri@libero.it
Research Domain of This Article
Pediatrics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 21, 2021; 27(23): 3303-3316 Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3303
Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review
Carmelina Calitri, Ilaria Fumi, Maria Giovanna Ignaccolo, Elena Banino, Stefania Benetti, Maria Maddalena Lupica, Francesca Fantone, Mariella Pace, Franco Garofalo
Carmelina Calitri, Ilaria Fumi, Maria Giovanna Ignaccolo, Elena Banino, Stefania Benetti, Maria Maddalena Lupica, Francesca Fantone, Mariella Pace, Franco Garofalo, Department of Paediatrics, Infermi Hospital, ASLTO3, Rivoli 10098, Italy
Author contributions: All the authors contributed equally to the work; the final version of the manuscript was revised and approved by all of the authors.
Conflict-of-interest statement: The authors declare no conflicts of interest in the subject matter of the submitted article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carmelina Calitri, MD, Doctor, Department of Paediatrics, Infermi Hospital, ASLTO3, Via Rivalta 29, Rivoli 10098, Italy. carmelina_calitri@libero.it
Received: January 28, 2021 Peer-review started: January 28, 2021 First decision: February 24, 2021 Revised: March 10, 2021 Accepted: May 24, 2021 Article in press: May 24, 2021 Published online: June 21, 2021
Core Tip
Core Tip: Gastrointestinal signs and symptoms seem to be more common in paediatric coronavirus disease 2019 (COVID-19) compared to adults. Manifestations are generally self-limited, and may only require supportive treatment. In a minority of children, gastrointestinal involvement may precede severe forms such as the multisystem inflammatory syndrome. Conversely to what is expected, the COVID-19 impact on paediatric patients with chronic gastrointestinal diseases is limited, with no need for therapeutic regimen changes. However, the severe acute respiratory syndrome coronavirus 2 pandemic determined multiple variations in routine practice. The use of telemedicine and telehealth can be a solution in order to continue to provide regular follow-up to chronic patients, avoiding the risk of viral transmission.
