Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2021; 27(22): 3109-3120
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3109
Early serum albumin changes in patients with ulcerative colitis treated with tacrolimus will predict clinical outcome
Natsuki Ishida, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
Natsuki Ishida, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Ken Sugimoto, First Department of Medicine, Hamamatsu University of School of Medicine, Hamamatsu 431-3192, Japan
Moriya Iwaizumi, Department of Laboratory Medicine, Hamamatsu University of School of Medicine, Hamamatsu 431-3192, Japan
Satoshi Osawa, Department of Endoscopic and Photodynamic Medicine, Hamamatsu University of School of Medicine, Hamamatsu 431-3192, Japan
Takahisa Furuta, Center for Clinical Research, Hamamatsu University of School of Medicine, Hamamatsu 43131, Japan
Author contributions: Ishida N contributed to this work; Ishida N and Sugimoto K designed the study; Sugimoto K, Miyazu T, Tamura S, and Tani S collected the data; Yamade M, Iwaizumi M, and Hamaya Y analyzed the data; Ishida N and Sugimoto K wrote the paper; Osawa S and Furuta T provided critical insights regarding paper preparation.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Hamamatsu University School of Medicine (No. 20-356).
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors received no financial support for the research, authorship, and/or publication of this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ken Sugimoto, MD, PhD, Associate Professor, First Department of Medicine, Hamamatsu University of School of Medicine, 1-20-1 Handayama Higashi-ku Hamamatsu, Hamamatsu 431-3192, Japan. sugimken@hama-med.ac.jp
Received: March 5, 2021
Peer-review started: March 5, 2021
First decision: March 27, 2021
Revised: April 11, 2021
Accepted: May 22, 2021
Article in press: May 22, 2021
Published online: June 14, 2021
Core Tip

Core Tip: The usefulness of serum albumin as a predictor of the therapeutic effect of oral tacrolimus for ulcerative colitis was investigated. Lower albumin levels in week 2 than in week 0 after achieving trough levels of tacrolimus were shown to increase risk for failure, including colectomy and switch to biologics, within 3 mo. In these cases, changes to other treatment options, including surgical total colectomy, should be considered as soon as possible.