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World J Gastroenterol. Jun 14, 2021; 27(22): 3010-3021
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3010
Role of bile acids in liver diseases mediated by the gut microbiome
Jun-Wei Shao, Tian-Tian Ge, Sen-Zhong Chen, Gang Wang, Qin Yang, Chun-Hong Huang, Li-Chen Xu, Zhi Chen
Jun-Wei Shao, Tian-Tian Ge, Sen-Zhong Chen, Gang Wang, Qin Yang, Chun-Hong Huang, Li-Chen Xu, Zhi Chen, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Chen Z, Shao JW and Ge TT carried out the concepts and designed the definition of intellectual content; Shao JW, Chen SZ and Yang Q carried out the literature search and manuscript editing. Wang G, Huang CH and Xu LC performed manuscript review; All authors have read and approved the content of the manuscript.
Supported by National Science and Technology Major Project of China, No. 2018ZX10302206.
Conflict-of-interest statement: The authors declare that there is no conflict of interests regarding the publication of this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi Chen, MD, PhD, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. zjuchenzhi@zju.edu.cn
Received: November 14, 2020
Peer-review started: November 14, 2020
First decision: February 28, 2021
Revised: March 8, 2021
Accepted: April 26, 2021
Article in press: April 26, 2021
Published online: June 14, 2021
Processing time: 205 Days and 19.9 Hours
Core Tip

Core Tip: This review explores the interaction between the gut microbiome, bile acids and liver disease. Bile acids are involved in liver immune and inflammatory responses via the membrane receptor G protein-coupled bile acid receptor 1 and the intracellular farnesoid-X receptor. The interaction between the gut microbiome and bile acids can control host immunological homeostasis and inhibit liver inflammation.