Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2021; 27(21): 2895-2909
Published online Jun 7, 2021. doi: 10.3748/wjg.v27.i21.2895
Clinicopathological characteristics and prognosis of 232 patients with poorly differentiated gastric neuroendocrine neoplasms
Deng Han, Yuan-Liang Li, Zhi-Wei Zhou, Fei Yin, Jie Chen, Fang Liu, Yan-Fen Shi, Wei Wang, Yu Zhang, Xian-Jun Yu, Jian-Ming Xu, Run-Xiang Yang, Chao Tian, Jie Luo, Huang-Ying Tan
Deng Han, Yuan-Liang Li, Chao Tian, Huang-Ying Tan, Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China
Zhi-Wei Zhou, Wei Wang, Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Fei Yin, Department of Gastroenterology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Jie Chen, Yu Zhang, Department of Gastroenterology, The First Affiliated Hospital Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Fang Liu, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Yan-Fen Shi, Jie Luo, Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China
Xian-Jun Yu, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Xian-Jun Yu, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Xian-Jun Yu, Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China
Xian-Jun Yu, Shanghai Pancreatic Cancer Institute, Shanghai 200032, China
Jian-Ming Xu, Department of Gastrointestinal Oncology, Affiliated Hospital Cancer Center, Academy of Military Medical Sciences, Beijing 100071, China
Run-Xiang Yang, Second Department of Internal Medicine, Yunnan Tumor Hospital, Kunming 650118, Yunnan Province, China
Author contributions: Han D and Li YL made equal contributions to this paper and should be regarded as a co-first authors; Han D collected and analyzed the data and wrote the manuscript; Li YL collected and analyzed the data; Zhou ZW, Yin F, Chen J, Yu XJ, Xu JM, and Yang RX provided data support; Wang W, Zhang Y, and Tian C helped with the follow-up of the patients; Liu F performed endoscopic examinations; Shi YF and Luo J reviewed the specimens for pathological diagnosis; Tan HY designed the study and critically revised the manuscript; all authors read and approved the final manuscript.
Supported by National Key R&D Program of China, No. 2019YFB1309704.
Institutional review board statement: This study was approved by the Clinical Research Ethics Committee of China-Japan Friendship Hospital (No. 2019-24-K18-1).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors have no competing interests to declare.
Data sharing statement: The data used to support the findings of this study are available from the various centers.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huang-Ying Tan, MD, PhD, Chief Physician, Department of Integrative Oncology, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China. tanhuangying@263.net
Received: January 26, 2021
Peer-review started: January 26, 2021
First decision: April 5, 2021
Revised: April 14, 2021
Accepted: May 7, 2021
Article in press: May 7, 2021
Published online: June 7, 2021
Processing time: 120 Days and 22.8 Hours
Core Tip

Core Tip: Most patients with poorly differentiated gastric neuroendocrine neoplasms (PDGNENs) present with lymph node metastasis or distant metastasis at the time of diagnosis, and the 5-year overall survival rate of patients with PDGNENs is only 5%. The malignancy of PDGNENs is very high, and the onset is relatively unclear. Routine gastroscopy may help detect PDGNENs as early as possible. Patients with a tumor diameter > 5 cm, multiple tumors, and with American Joint Committee on Cancer stage III or IV have a poor prognosis.