Frontier
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2021; 27(19): 2257-2269
Published online May 21, 2021. doi: 10.3748/wjg.v27.i19.2257
Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease
Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo
Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan
Author contributions: Hara A, Watanabe T, and Minaga K drafted the manuscript; Yoshikawa T, Kamata K, and Kudo M edited and revised the manuscript; Hara A, Watanabe T, Minaga K, Yoshikawa T, Kamata K and Kudo M have read and approved the final manuscript; all authors therefore meet the criteria for authorship established by the International Committee of Medical Journal Editors.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tomohiro Watanabe, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama 589-8511, Japan. tomohiro@med.kindai.ac.jp
Received: February 11, 2021
Peer-review started: February 11, 2021
First decision: March 14, 2021
Revised: March 19, 2021
Accepted: April 26, 2021
Article in press: April 26, 2021
Published online: May 21, 2021
Core Tip

Core Tip: Autoimmune pancreatitis (AIP) and immunoglobulin G4-related disease (IgG4-RD) are new disease entities characterized by enhanced IgG4 antibody responses. Serum concentration of IgG4 antibody is widely used as a useful biomarker for diagnosis and disease activity monitoring in AIP and IgG4-RD. Recent studies have highlighted the importance of cytokine responses in the immunopathogenesis of these disorders. In this Frontier article, we have summarized our knowledge regarding cytokine responses in AIP and IgG4-RD and then discussed the utility of serum concentrations of cytokines as possible biomarkers.