Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2021; 27(12): 1182-1193
Published online Mar 28, 2021. doi: 10.3748/wjg.v27.i12.1182
R2* value derived from multi-echo Dixon technique can aid discrimination between benign and malignant focal liver lesions
Guang-Zi Shi, Hong Chen, Wei-Ke Zeng, Ming Gao, Meng-Zhu Wang, Hui-Ting Zhang, Jun Shen
Guang-Zi Shi, Hong Chen, Wei-Ke Zeng, Ming Gao, Jun Shen, Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong Province, China
Meng-Zhu Wang, Hui-Ting Zhang, MR Scientific Marketing, Siemens Healthineers, Guangzhou 510120, Guangdong Province, China
Author contributions: Shi GZ and Chen H contributed equally to this work; Shi GZ and Shen J designed the research; Shi GZ, Chen H, Zeng WK, and Wang MZ collected and analyzed the data; Shi GZ wrote the manuscript; Shi GZ, Chen H, Zeng WK, Gao M, Wang MZ, and Zhang HT analyzed and interpreted the data; Shen J wrote and revised the manuscript; all co-authors participated in writing and checking the manuscript, and approved the submitted manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Sun Yat-Sen Memorial Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jun Shen, MD, Doctor, Professor, Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang Road West, Guangzhou 510120, Guangdong Province, China.
Received: November 20, 2020
Peer-review started: November 20, 2020
First decision: January 23, 2021
Revised: February 2, 2021
Accepted: February 25, 2021
Article in press: February 25, 2021
Published online: March 28, 2021
Core Tip

Core Tip: Our study showed that mean R2* value of malignant focal liver lesions (FLLs) was significantly higher than that of benign FLLs. R2* derived from multi-echo Dixon imaging is a potential biomarker to differentiate malignant from benign FFLs. The multi-echo Dixon sequence is easy to perform and requires only a single breath-hold of 16 s to image the entire liver, which holds a good potential for clinical application.