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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2021; 27(11): 1101-1116
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1101
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1101
Long-term follow-up of cumulative incidence of hepatocellular carcinoma in hepatitis B virus patients without antiviral therapy
Xiao-Yan Jiang, Bing Huang, Department of Gastroenterology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong Province, China
Dan-Ping Huang, Chun-Shan Wei, Wei-Chao Zhong, De-Ti Peng, Fu-Rong Huang, Guang-Dong Tong, Department of Hepatology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong Province, China
Author contributions: Tong GD conceived, supervised and guided implementation of the experiments; Jiang XY, Huang B, Huang DP and Wei CS conducted the experiments, collected and organized the data, and analyzed the results; Zhong WC, Peng DT and Huang FR wrote the original draft; all the authors revised the manuscript and approved the final version.
Supported by National Natural Science Foundation of China , No. 81174263 ; Sanming Project of Medicine in Shenzhen , Guangdong Province, China, No. SZSM201612074; and Shenzhen Science and Technology Project , Guangdong Province, China, No. 201202154.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine.
Clinical trial registration statement: This study was registered at Chinese Clinical Trial Registry (http: //www.chictr.org.cn/index.aspx). The registration identification number is ChiCTR2000029281 (1/20/2020).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors and study participants declare no potential conflicting interests related to this paper.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang-Dong Tong, MD, PhD, Chief Physician, Professor, Department of Hepatology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, No. 1 Fuhua Road, Shenzhen 518033, Guangdong Province, China. tgd755@163.com
Received: November 20, 2020
Peer-review started: November 20, 2020
First decision: December 17, 2020
Revised: January 7, 2021
Accepted: February 11, 2021
Article in press: February 11, 2021
Published online: March 21, 2021
Processing time: 117 Days and 3.9 Hours
Peer-review started: November 20, 2020
First decision: December 17, 2020
Revised: January 7, 2021
Accepted: February 11, 2021
Article in press: February 11, 2021
Published online: March 21, 2021
Processing time: 117 Days and 3.9 Hours
Core Tip
Core Tip: According to the status quo of antiviral therapy for chronic hepatitis B (CHB) in China, we conducted long-term follow-up of patients with CHB who were recommended to receive nucleoside antiviral therapy in accordance with the guidelines, but did not receive antiviral therapy. We found that early antiviral therapy in patients with CHB did not yield greater benefits in the incidence of hepatocellular carcinoma than hepatoprotective anti-inflammatory therapy. It is suggested that early antiviral therapy with nucleosides may mask spontaneous viral clearance and hepatitis B e antigen clearance in patients with CHB.