Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2021; 27(10): 939-958
Published online Mar 14, 2021. doi: 10.3748/wjg.v27.i10.939
Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing CCNB1 expression
Min Li, Hua Shang, Tao Wang, Shui-Qing Yang, Lei Li
Min Li, Hua Shang, Department of Gastroenterology, Zibo Central Hospital, Zibo 255036, Shandong Province, China
Tao Wang, Department of General Surgery, Zibo Central Hospital, Zibo 255036, Shandong Province, China
Shui-Qing Yang, Lei Li, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
Lei Li, Department of Pathology, University of Otago, Dunedin px806, New Zealand
Author contributions: Li L conceived and performed the experiments and drafted the article; Li M and Shuang H conceived and performed partial experiments; Wang T and Yang SQ designed the study, supervised the experiments, and revised the article; all authors read and approved the final manuscript.
Institutional review board statement: Animal and human experiments were not conducted in this study.
Conflict-of-interest statement: The authors declare that there are no competing interests associated with the manuscript.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at [wshililei@buaa.edu.cn].
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Li, PhD, Academic Research, Department of Pathology, University of Otago, 270 Great King Street, Dunedin px806, New Zealand. wshililei@buaa.edu.cn
Received: November 26, 2020
Peer-review started: November 26, 2020
First decision: December 21, 2020
Revised: January 3, 2021
Accepted: February 1, 2021
Article in press: February 1, 2021
Published online: March 14, 2021
Processing time: 105 Days and 3.1 Hours
Core Tip

Core Tip: The purpose of this study was to investigate the role and mechanism of Huanglian decoction on hepatocellular carcinoma (HCC) cells. The results showed that Huanglian decoction has a significant inhibitory effect on the growth of HCC cells. Huanglian decoction can inhibit HCC cell growth by downregulating the expression of CCNB1 to activate the p53 signaling pathway. CCNB1 is a potential therapeutic target for liver cancer.