Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2020; 26(5): 456-465
Published online Feb 7, 2020. doi: 10.3748/wjg.v26.i5.456
Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives
Marcella Pesce, Martina Cargiolli, Sara Cassarano, Barbara Polese, Barbara De Conno, Laura Aurino, Nicola Mancino, Giovanni Sarnelli
Marcella Pesce, Martina Cargiolli, Sara Cassarano, Barbara Polese, Barbara De Conno, Laura Aurino, Nicola Mancino, Giovanni Sarnelli, Department of Clinical Medicine and Surgery, “Federico II” University of Naples, Naples 80131, Italy
Marcella Pesce, GI Physiology Unit, University College London Hospital, London NW1 2BU, United Kingdom
Author contributions: Pesce M and Sarnelli G conceived the manuscript and contributed to drafting, critical revision and editing; Cargiolli M, Polese B and Cassarano S carried out literature review and analysis and contributed to writing the manuscript. De Conno B, Aurino L and Mancino N contributed to this paper with literature review and analysis and editing; all authors gave final approval of the paper.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Giovanni Sarnelli, MD, PhD, Associate Professor, Department of Clinical Medicine and Surgery, Federico II University of Naples, Via Pansini 5, Naples 80131, Italy.
Received: November 15, 2019
Peer-review started: November 15, 2019
First decision: December 12, 2019
Revised: December 24, 2019
Accepted: January 19, 2020
Article in press: January 19, 2020
Published online: February 7, 2020
Core Tip

Core tip: The spread on the internet of indiscriminate exclusion diets and food intolerance tests often reinforces in patients with functional dyspepsia (FD) the idea of being allergic or intolerant to foods. Physicians are often uncertain regarding the contribution of specific foods in FD and the lack of guidelines and dedicated dietitians, ultimately, leads to conflicting and uneven dietary advises. Here, we provide a pathophysiological-based review of the putative causal relationship between specific foods and symptoms generation in FD and then provide an evidence-based standardized dietary approach, applicable in clinical practice. Moving forward, international guidelines are eagerly awaited to standardize FD dietary management.