Sun X, Huang Y, Zhang YL, Qiao D, Dai YC. Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells. World J Gastroenterol 2020; 26(48): 7593-7602 [PMID: 33505138 DOI: 10.3748/wjg.v26.i48.7593]
Corresponding Author of This Article
Yan-Cheng Dai, PhD, Chief Doctor, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Shanghai 200082, China. daiyancheng2005@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 28, 2020; 26(48): 7593-7602 Published online Dec 28, 2020. doi: 10.3748/wjg.v26.i48.7593
Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells
Xiong Sun, Yao Huang, Ya-Li Zhang, Dan Qiao, Yan-Cheng Dai
Xiong Sun, Department of Gastroenterology, Shanghai PuTuo District People's Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai 200060, China
Yao Huang, Department of Digestive Diseases, Jing'an District Central Hospital, Fudan University, Shanghai 200040, China
Ya-Li Zhang, Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Dan Qiao, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China
Yan-Cheng Dai, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China. daiyancheng2005@126.com
Author contributions: Sun X and Dai YC designed the research; Huang Y and Qiao D analyzed the data; Sun X, Huang Y, and Dai YC wrote the paper; Sun X and Zhang YL made critical revisions related to important content of the revised manuscript; Sun X, Huang Y, Zhang YL, Qiao D, and Dai YC provided the final approval of the version to be published.
Supported byNational Natural Science Foundation of China, No. 81873253; Key Clinical Specialty Construction Project Supported by Hongkou District Health Committee, No. HKZK2020A01; Sixth Round of Academic Experience Successors Training Project for Veteran Practitioner of Traditional Chinese Medicine, the document of the State Administration of Traditional Chinese Medicine, 2017 No. 29.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access:
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
Corresponding author: Yan-Cheng Dai, PhD, Chief Doctor, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Shanghai 200082, China. daiyancheng2005@126.com
Received: September 29, 2020 Peer-review started: September 29, 2020 First decision: November 8, 2020 Revised: November 14, 2020 Accepted: November 29, 2020 Article in press: November 29, 2020 Published online: December 28, 2020 Processing time: 87 Days and 8.7 Hours
Core Tip
Core Tip: The pathophysiology of ulcerative colitis remains unclear. Vasoactive intestinal peptide (VIP) is a neuropeptide that has strong regulatory activity on intestinal immunity. With further clarity on the mechanism of the regulation of interleukin-10 expression by VIP in regulatory B cells in colitis patients, we believe that VIP can provide a novel strategy for the clinical treatment of ulcerative colitis.