Prospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2020; 26(46): 7416-7424
Published online Dec 14, 2020. doi: 10.3748/wjg.v26.i46.7416
Value of shear wave elastography with maximal elasticity in differentiating benign and malignant solid focal liver lesions
Hui-Ping Zhang, Ji-Ying Gu, Min Bai, Fan Li, Yu-Qing Zhou, Lian-Fang Du
Hui-Ping Zhang, Yu-Qing Zhou, Department of Ultrasound, Shanghai Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200050, China
Ji-Ying Gu, Department of Ultrasound, Shanghai Fourth People’s Hospital, Shanghai Tongji University School of Medicine, Shanghai 200434, China
Min Bai, Fan Li, Lian-Fang Du, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China
Author contributions: Zhang HP designed the study, drafted the manuscript, and assisted with the data analysis; Gu JY performed ultrasound elastography examinations; Bai M performed conventional ultrasound examinations; Li F collected data and assisted with the data analysis; Zhou YQ drafted the manuscript and performed statistical analysis; Du LF designed the study and drafted the manuscript; All authors read and approved the final manuscript.
Supported by Natural Science Foundation of Shanghai of China, No. 19ZR1441500.
Institutional review board statement: The study was approved by the Ethics Committee of Shanghai First People’s Hospital.
Clinical trial registration statement: This study is registered at clinical hospital center “Shanghai General Hospital, Shanghai Jiaotong University School of Medicine” trial registry. Registration identification, No. ChiCTR1800016590.
Informed consent statement: Written informed consent was obtained from every patient.
Conflict-of-interest statement: The authors of this manuscript having no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Lian-Fang Du, MD, Chief Doctor, Full Professor, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.
Received: September 18, 2020
Peer-review started: September 18, 2020
First decision: October 17, 2020
Revised: October 30, 2020
Accepted: November 13, 2020
Article in press: November 13, 2020
Published online: December 14, 2020
Core Tip

Core Tip: Shear wave elastography (SWE) has been used with promising results in the assessment of liver fibrosis and in the differential diagnosis of thyroid and breast nodules. However, its value for the differential diagnosis between malignant and benign focal liver lesions (FLLs) is still investigational. In this study, instead of the common parameter (mean elasticity), we used maximal elasticity (Emax) as the parameter to explore the value of SWE in the differential diagnosis of FLLs. Our results showed that Emax is useful for differential diagnosis of FLLs, especially in combination with conventional ultrasound.