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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2020; 26(46): 7382-7404
Published online Dec 14, 2020. doi: 10.3748/wjg.v26.i46.7382
Published online Dec 14, 2020. doi: 10.3748/wjg.v26.i46.7382
Prognostic value of the preoperative fibrinogen-to-albumin ratio in pancreatic ductal adenocarcinoma patients undergoing R0 resection
Li-Peng Zhang, Hu Ren, Yong-Xing Du, Cheng-Feng Wang, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Cheng-Feng Wang, State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhang LP was involved in study concept, data analysis, and production of tables, wrote the first draft, and revised it critically in light of comments from other authors; Ren H and Du YX helped to collect the clinical data and followed up with the patients; Wang CF was involved in study conception and design, data interpretation, manuscript revision, and discussion; all authors approved the final version submitted.
Supported by National Natural Science Foundation of China , No. 81972314 ; and Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences , No. 2016-I2M-1-001 .
Institutional review board statement: The study was reviewed and approved by The National Cancer Center/Cancer Hospital of the Chinese Academy of Medical Sciences.
Informed consent statement: All patients and their families signed informed consent statements before surgery, and the type of surgical procedure was performed according to the authoritative guidelines.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cheng-Feng Wang, MD, Chief Doctor, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.
Received: September 23, 2020
Peer-review started: September 23, 2020
First decision: October 27, 2020
Revised: October 29, 2020
Accepted: November 13, 2020
Article in press: November 13, 2020
Published online: December 14, 2020
Processing time: 82 Days and 4.7 Hours
Peer-review started: September 23, 2020
First decision: October 27, 2020
Revised: October 29, 2020
Accepted: November 13, 2020
Article in press: November 13, 2020
Published online: December 14, 2020
Processing time: 82 Days and 4.7 Hours
Core Tip
Core Tip: Inflammation plays an important role in the occurrence and development of tumors. Recently, many retrospective studies have reported the significance of the fibrinogen-to-albumin ratio in the prognosis of patients with malignant tumors, but there have been no reports of patients with resectable pancreatic cancer. We studied 282 patients with pancreatic ductal adenocarcinoma who underwent radical R0 resection, and we found that the preoperative fibrinogen-to-albumin ratio is an easily available, cost-effective, and noninvasive prognostic indicator for pancreatic ductal adenocarcinoma patients undergoing radical R0 resection.