Xue LJ, Han JQ, Zhou YC, Peng HY, Yin TF, Li KM, Yao SK. Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats. World J Gastroenterol 2020; 26(46): 7299-7311 [PMID: 33362385 DOI: 10.3748/wjg.v26.i46.7299]
Corresponding Author of This Article
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Li-Jun Xue, Shu-Kun Yao, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
Ju-Qiang Han, Department of Hepatology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China
Yuan-Chen Zhou, Hong-Ye Peng, Teng-Fei Yin, Kai-Min Li, Shu-Kun Yao, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Xue LJ, Zhou YC, Peng HY and Yin TF performed the experiments; Xue LJ analyzed the data, prepared figures and contributed to the drafting of the manuscript; Yao SK and Han JQ supervised this work and edited and revised manuscript; Yao SK initiated the project, design the experiments and approved the final version of manuscript; Li KM provided technical assistance; All authors read and approved the final manuscript.
Supported byScience and Technology Project Task Book of Beijing, No. Z171100001717008.
Institutional animal care and use committee statement: The study was approved by the Animal Care Committees at China-Japan Friendship Hospital (Approval No: 190201).
Conflict-of-interest statement: All authors report no conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the first author at lijuner_080629@163.com.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Received: August 17, 2020 Peer-review started: August 17, 2020 First decision: October 18, 2020 Revised: October 27, 2020 Accepted: November 9, 2020 Article in press: November 9, 2020 Published online: December 14, 2020 Processing time: 118 Days and 15.6 Hours
Core Tip
Core Tip: For some patients with normal body mass index and normal serum indexes, liver damage may already exist. In our previous analysis of clinical data and a high-risk factor questionnaire for patients with nonalcoholic fatty liver disease (NAFLD), we found that the body mass index of some patients did not meet the diagnostic criteria for overweight or obesity. The consumption of high-temperature-processed foods such as fried food and hot pot is closely associated with the occurrence of NAFLD. Dietary intervention to reduce the consumption of such foods can alleviate NAFLD and improve prognosis. For patients with mild liver fat changes and early fibrosis, some clinical equipment and means of diagnosis are prone to misdiagnosis. Untargeted metabolomics can preliminarily explain the difference in liver pathology in the three groups of rats.
