Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2020; 26(43): 6795-6809
Published online Nov 21, 2020. doi: 10.3748/wjg.v26.i43.6795
Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models
Michelle Liz de Souza Pessoa, Leiliane Macena Oliveira Silva, Maria Elaine Cristina Araruna, Catarina Alves de Lima Serafim, Edvaldo Balbino Alves Júnior, Alessa Oliveira Silva, Matheus Marley Bezerra Pessoa, Hermes Diniz Neto, Edeltrudes de Oliveira Lima, Leônia Maria Batista
Michelle Liz de Souza Pessoa, Leiliane Macena Oliveira Silva, Maria Elaine Cristina Araruna, Catarina Alves de Lima Serafim, Edvaldo Balbino Alves Júnior, Alessa Oliveira Silva, Hermes Diniz Neto, Edeltrudes de Oliveira Lima, Department of Pharmaceutical Sciences, IPeFarM, Federal University of Paraíba, João Pessoa 58051-970, Paraíba, Brazil
Matheus Marley Bezerra Pessoa, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, Paraíba, Brazil
Leônia Maria Batista, Postgraduate Program in Natural and Synthetic Bioactive Products, Universidade Federal da Paraiba, João Pessoa 58051-900, Brazil
Author contributions: Pessoa MLS, Silva LMO, Araruna MEC, Serafim CAL, Alves Júnior EB, Silva AO, Pessoa MMB, and Batista LM contributed to the conception and design of the study, performed the in vivo experiments, coordinated the study, participated in writing the manuscript and approved the final version to be published; Diniz Neto H and de Oliveira Lima E acted as contributors to the evaluation of antimicrobial activity.
Institutional review board statement: The study was reviewed and approved by the Commission for Ethics in Animal Experimentation (CEUA) of the Research Ethics Committee of the Federal University of Paraíba.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (approved by the Institutional Commission in Animal Use from Federal University of Paraíba (CEUA/UFPB) under No. 035/2017 and No. 4996090518/2018).
Conflict-of-interest statement: Authors declare that no conflict of interest exists.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Leônia Maria Batista, PharmD, Associate Professor, Professor, Postgraduate Program in Natural and Synthetic Bioactive Products, Universidade Federal da Paraiba, Cidade Universitária, s/n - Castelo Branco III, João Pessoa 58051-900, Brazil. leoniab@uol.com.br
Received: May 20, 2020
Peer-review started: May 20, 2020
First decision: July 29, 2020
Revised: August 12, 2020
Accepted: October 1, 2020
Article in press: October 1, 2020
Published online: November 21, 2020
Processing time: 178 Days and 8.6 Hours
Core Tip

Core Tip: (-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species, such as Foeniculum vulgare and Peumus boldus, used to treatment of gastrointestinal diseases. Diarrhea is a pathological condition characterized by an increase in three or more defecations in 24 h, being of multiple origins, whether infectious or not. In the search for new therapeutic alternatives, natural products, and medicinal plants are of great relevance. Many species of plants and their isolated compounds, including terpenes, have shown promising antidiarrheal and motility, based on this result, the monoterpene (-)-fenchone was selected for this study.