Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2020; 26(42): 6556-6571
Published online Nov 14, 2020. doi: 10.3748/wjg.v26.i42.6556
What could microRNA expression tell us more about colorectal serrated pathway carcinogenesis?
Milena Peruhova, Monika Peshevska-Sekulovska, Boris Krastev, Gabriela Panayotova, Viktoriya Georgieva, Rossitza Konakchieva, Georgi Nikolaev, Tsvetelina Veselinova Velikova
Milena Peruhova, Monika Peshevska-Sekulovska, Gabriela Panayotova, Viktoriya Georgieva, Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria
Milena Peruhova, Gabriela Panayotova, Tsvetelina Veselinova Velikova, Medical Faculty, Sofia University St. Kliment Ohridski, Sofia 1407, Bulgaria
Boris Krastev, Department of Clinical Oncology, MHAT Hospital for Women Health Nadezhda, Sofia 1330, Bulgaria
Rossitza Konakchieva, Georgi Nikolaev, Faculty of Biology, Sofia University St. Kliment Ohridski, Sofia 1407, Bulgaria
Tsvetelina Veselinova Velikova, Department of Clinical Immunology, University Hospital Lozenetz, Sofia 1407, Bulgaria
Author contributions: Peruhova M wrote the draft; all the authors wrote additional sections in the paper; and all authors revised and approved the final version of the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Tsvetelina Veselinova Velikova, MD, PhD, Assistant Professor, Research Scientist, Department of Clinical Immunology, University Hospital Lozenetz, Kozyak 1 Street, Sofia 1407, Bulgaria.
Received: August 29, 2020
Peer-review started: August 29, 2020
First decision: September 12, 2020
Revised: September 24, 2020
Accepted: October 20, 2020
Article in press: October 20, 2020
Published online: November 14, 2020
Core Tip

Core Tip: In addition to the adenoma to carcinoma transition, colorectal carcinogenesis can also occur via the serrated pathway. In most serrated polyps, the pathway is believed to include the acquisition of a mutation in a gene that regulates mitogen-activated protein kinase (MAPK) pathway, disruptions to the Wnt signaling pathway and widespread methylation of CpG islands. Moreover, there are less data about different microRNAs (miRNAs) expression profiling in serrated adenomas with different grades of dysplasia. In contrast to the conventional colorectal carcinogenesis, the pivotal role of miRNAs and their relevant signaling pathways in the serrated pathway of carcinogenesis is still to be elucidated because of an insufficient number of studies conducted to clarify separate steps in the process.